Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …

The extracellular matrix (ECM) is a complex network of extracellular-secreted
macromolecules, such as collagen, enzymes and glycoproteins, whose main functions deal …

Tumor-resident intracellular microbiota is an emerging tumor component that has been
documented for a variety of cancer types with unclear biological functions. Here, we …

There is no effective method to predict chemotherapy response and postoperative prognosis
of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has …

Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive
functions, but the mechanisms underlying these opposing effects remain elusive. Here, we …

Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …

Half of the children diagnosed with neuroblastoma (NB) have high-risk disease,
disproportionately contributing to overall childhood cancer-related deaths. In addition to …

Colorectal cancer (CRC) is a serious disease that affects millions of people throughout the
world, despite considerable advances in therapy. The formation of colorectal adenomas and …

Objectives PD-L1 expression on tumour cells can guide the use of anti-PD-1/PD-L1 immune
modulators to treat patients with non-small cell lung cancer (NSCLC). Heterogeneity of PD …

In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of
metastasized CRC. Here we present whole genome sequencing data of metastases of 429 …