Despite the challenges posed by drug resistance and side effects, chemotherapy remains a
pivotal strategy in cancer treatment. A key issue in this context is macroautophagy …

Autophagy, a crucial intracellular degradation process facilitated by lysosomes, plays a
pivotal role in maintaining cellular homeostasis. The elucidation of autophagy key genes …

This review aims to provide a comprehensive understanding of the molecular mechanisms
underlying autophagy and mitophagy in hepatocellular carcinoma (HCC). Autophagy is an …

Chemoresistance is a major challenge in treating triple‑negative breast cancer (TNBC);
chemotherapy remains the primary approach. The present study aimed to elucidate the role …

A series of novel urea derivatives were designed, synthesized and evaluated for their
inhibitory activities against HT-29 cells, and structure-activity relationships (SAR) were …

Abstract Bacterial-extracellular-vesicles (BEVs) derived from Escherichia coli, strain-A5922,
were used as a therapeutic tool to treat colon cancer cells, HT-29. BEVs induced oxidative …

In recent years, colon cancer has become one of the most common malignant tumors
worldwide, posing a great threat to human health. Studies have shown that natural …

Chloroquine (CQ) and its derivate hydroxychloroquine (HCQ), the compounds with
recognized ability to suppress autophagy, have been tested in experimental works and in …

Cancer is the result of genetic abnormalities that cause normal cells to grow into neoplastic
cells. Cancer is characterized by several distinct features, such as uncontrolled cell growth …

Arsenic trioxide (ATO) has gained significant attention due to its promising therapeutic
effects in treating different diseases, particularly acute promyelocytic leukemia (APL). Its …