[HTML][HTML] The burden and risks of emerging complications of diabetes mellitus

D Tomic, JE Shaw, DJ Magliano - Nature Reviews Endocrinology, 2022 - nature.com
The traditional complications of diabetes mellitus are well known and continue to pose a
considerable burden on millions of people living with diabetes mellitus. However, advances …

[HTML][HTML] 4. Comprehensive medical evaluation and assessment of comorbidities: Standards of Care in Diabetes—2023

NA ElSayed, G Aleppo, VR Aroda, RR Bannuru… - Diabetes …, 2023 - ncbi.nlm.nih.gov
The American Diabetes Association (ADA)“Standards of Care in Diabetes” includes the
ADA's current clinical practice recommendations and is intended to provide the components …

Current understanding of the molecular and cellular pathology of diabetic retinopathy

DA Antonetti, PS Silva, AW Stitt - Nature Reviews Endocrinology, 2021 - nature.com
Diabetes mellitus has profound effects on multiple organ systems; however, the loss of
vision caused by diabetic retinopathy might be one of the most impactful in a patient's life …

[HTML][HTML] Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

[HTML][HTML] Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

H Querfurth, HK Lee - Molecular neurodegeneration, 2021 - Springer
Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

C Soto, S Pritzkow - Nature neuroscience, 2018 - nature.com
A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

[HTML][HTML] Vascular cognitive impairment (VCI)

T Rundek, M Tolea, T Ariko, EA Fagerli, CJ Camargo - Neurotherapeutics, 2023 - Elsevier
Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

GJ Biessels, F Despa - Nature Reviews Endocrinology, 2018 - nature.com
Cognitive dysfunction is increasingly recognized as an important comorbidity of diabetes
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …

[HTML][HTML] Inflammation as a central mechanism in Alzheimer's disease

JW Kinney, SM Bemiller, AS Murtishaw… - Alzheimer's & Dementia …, 2018 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

Treatment of diabetes in older adults: an Endocrine Society clinical practice guideline

D LeRoith, GJ Biessels, SS Braithwaite… - The Journal of …, 2019 - academic.oup.com
Objective The objective is to formulate clinical practice guidelines for the treatment of
diabetes in older adults. Conclusions Diabetes, particularly type 2, is becoming more …