The emergence of a nucleosome-based chromatin structure accompanied the evolutionary
transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the …

Abstract SAGA (Spt-Ada-Gcn5 acetyltransferase) is a highly conserved transcriptional
coactivator that consists of four functionally independent modules. Its two distinct enzymatic …

Ubiquitination-dependent histone crosstalk plays critical roles in chromatin-associated
processes and is highly associated with human diseases. Mechanism studies of the …

DOT1L is a histone H3 Lys79 methyltransferase whose activity is stimulated by histone H2B
Lys120 ubiquitination, suggesting cross-talk between histone H3 methylation and H2B …

Histone ubiquitylation is a critical part of both active and repressed transcriptional states,
and lies at the heart of DNA damage repair signaling. The histone residues targeted for …

Histone methylation plays a key function in modulating gene expression, and preserving
genome integrity and epigenetic inheritance. However, aberrations of histone methylation …

Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …

Eukaryotic organisms adapt to environmental fluctuations by altering their epigenomic
landscapes and transcriptional programs. Nucleosomal histones carry vital epigenetic …

Post-translational modifications of histone proteins often mediate gene regulation by altering
the global and local stability of the nucleosome, the basic gene-packing unit of eukaryotes …

Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …