Biosynthesis and biological activities of newly discovered Amaryllidaceae alkaloids

S Ka, M Koirala, N Mérindol, I Desgagné-Penix - Molecules, 2020 - mdpi.com
Alkaloids are an important group of specialized nitrogen metabolites with a wide range of
biochemical and pharmacological effects. Since the first publication on lycorine in 1877 …

Non-canonical amino acids in analyses of protease structure and function

P Goettig, NG Koch, N Budisa - International Journal of Molecular …, 2023 - mdpi.com
All known organisms encode 20 canonical amino acids by base triplets in the genetic code.
The cellular translational machinery produces proteins consisting mainly of these amino …

Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease

D Hulcová, J Maříková, J Korábečný, A Hošťálková… - Phytochemistry, 2019 - Elsevier
Twenty-one known Amaryllidaceae alkaloids of various structural types and one
undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of …

Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease

A Hostalkova, J Marikova, L Opletal… - Journal of natural …, 2019 - ACS Publications
Three new alkaloids, bersavine (3), muraricine (4), and berbostrejdine (8), together with
seven known isoquinoline alkaloids (1–2, 5–7, 9, and 10) were isolated from an alkaloidal …

Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

MM Calvo, AB Martín-Diana, D Rico… - Foods, 2022 - mdpi.com
This study aims to determine the potential antioxidant, antihypertensive, hypoglycaemic and
nootropic activity of a purified polyphenolic extract from the halophyte ice plant …

Altered expression of DAAM1 and PREP induced by cadmium toxicity is counteracted by melatonin in the rat testis

M Venditti, M Ben Rhouma, MZ Romano, I Messaoudi… - Genes, 2021 - mdpi.com
Cadmium (Cd) is one of the most toxic pollutants for health due to its accumulation in several
tissues, including testis. This report confirms that Cd increased oxidative stress and …

Prolyl endopeptidase remodels macrophage function as a novel transcriptional coregulator and inhibits fibrosis

SZ Lin, WJ Wu, YQ Cheng, JB Zhang… - … & Molecular Medicine, 2023 - nature.com
Macrophages are immune cells crucial for host defense and homeostasis maintenance, and
their dysregulation is involved in multiple pathological conditions, such as liver fibrosis. The …

Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase

A Al Mamun, J Maříková, D Hulcová, J Janoušek… - Biomolecules, 2020 - mdpi.com
Thirteen known (1–12 and 16) and three previously undescribed Amaryllidaceae alkaloids
of belladine structural type, named carltonine AC (13–15), were isolated from bulbs of …

Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase

J Maríkova, A Ritomska, J Korabecny… - Journal of natural …, 2020 - ACS Publications
A total of 20 derivatives (1–20) of the crinane-type alkaloid ambelline were synthesized.
These semisynthetic derivatives were assessed for their potency to inhibit both …

Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile

K Sobolova, M Hrabinova, V Hepnarova… - European journal of …, 2020 - Elsevier
Berberine, a naturally occurring compound, possesses an interesting multipotent
pharmacological profile potentially applicable for Alzheimer's disease (AD) treatment. In this …