Biosynthesis and biological activities of newly discovered Amaryllidaceae alkaloids
Alkaloids are an important group of specialized nitrogen metabolites with a wide range of
biochemical and pharmacological effects. Since the first publication on lycorine in 1877 …
biochemical and pharmacological effects. Since the first publication on lycorine in 1877 …
Non-canonical amino acids in analyses of protease structure and function
All known organisms encode 20 canonical amino acids by base triplets in the genetic code.
The cellular translational machinery produces proteins consisting mainly of these amino …
The cellular translational machinery produces proteins consisting mainly of these amino …
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
D Hulcová, J Maříková, J Korábečný, A Hošťálková… - Phytochemistry, 2019 - Elsevier
Twenty-one known Amaryllidaceae alkaloids of various structural types and one
undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of …
undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of …
Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease
A Hostalkova, J Marikova, L Opletal… - Journal of natural …, 2019 - ACS Publications
Three new alkaloids, bersavine (3), muraricine (4), and berbostrejdine (8), together with
seven known isoquinoline alkaloids (1–2, 5–7, 9, and 10) were isolated from an alkaloidal …
seven known isoquinoline alkaloids (1–2, 5–7, 9, and 10) were isolated from an alkaloidal …
Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)
MM Calvo, AB Martín-Diana, D Rico… - Foods, 2022 - mdpi.com
This study aims to determine the potential antioxidant, antihypertensive, hypoglycaemic and
nootropic activity of a purified polyphenolic extract from the halophyte ice plant …
nootropic activity of a purified polyphenolic extract from the halophyte ice plant …
Altered expression of DAAM1 and PREP induced by cadmium toxicity is counteracted by melatonin in the rat testis
M Venditti, M Ben Rhouma, MZ Romano, I Messaoudi… - Genes, 2021 - mdpi.com
Cadmium (Cd) is one of the most toxic pollutants for health due to its accumulation in several
tissues, including testis. This report confirms that Cd increased oxidative stress and …
tissues, including testis. This report confirms that Cd increased oxidative stress and …
Prolyl endopeptidase remodels macrophage function as a novel transcriptional coregulator and inhibits fibrosis
SZ Lin, WJ Wu, YQ Cheng, JB Zhang… - … & Molecular Medicine, 2023 - nature.com
Macrophages are immune cells crucial for host defense and homeostasis maintenance, and
their dysregulation is involved in multiple pathological conditions, such as liver fibrosis. The …
their dysregulation is involved in multiple pathological conditions, such as liver fibrosis. The …
Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase
A Al Mamun, J Maříková, D Hulcová, J Janoušek… - Biomolecules, 2020 - mdpi.com
Thirteen known (1–12 and 16) and three previously undescribed Amaryllidaceae alkaloids
of belladine structural type, named carltonine AC (13–15), were isolated from bulbs of …
of belladine structural type, named carltonine AC (13–15), were isolated from bulbs of …
Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase
J Maríkova, A Ritomska, J Korabecny… - Journal of natural …, 2020 - ACS Publications
A total of 20 derivatives (1–20) of the crinane-type alkaloid ambelline were synthesized.
These semisynthetic derivatives were assessed for their potency to inhibit both …
These semisynthetic derivatives were assessed for their potency to inhibit both …
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
K Sobolova, M Hrabinova, V Hepnarova… - European journal of …, 2020 - Elsevier
Berberine, a naturally occurring compound, possesses an interesting multipotent
pharmacological profile potentially applicable for Alzheimer's disease (AD) treatment. In this …
pharmacological profile potentially applicable for Alzheimer's disease (AD) treatment. In this …