Concentration, motility and morphology are parameters commonly used to determine the
fertilization potential of an ejaculate. These parameters give a general view on the quality of …

A sequence variant of histone H2A called H2AX is one of the key components of chromatin
involved in DNA damage response induced by different genotoxic stresses. Phosphorylated …

Background Accumulation of DNA damage leading to adult stem cell exhaustion has been
proposed to be a principal mechanism of aging. Here we tested this hypothesis in healthy …

The reproductive consequences of global warming are not currently understood. In order to
address this issue, we have examined the reproductive consequences of exposing male …

Long term survival rates for childhood cancers is steadily increasing, however cancer
survivors can experience fertility problems as a consequence of chemotherapy treatment …

DNA damage is one of the most consistent cellular process proposed to contribute to aging.
The maintenance of genomic and epigenomic integrity is critical for proper function of cells …

Introduction and objective. In the light of current data concerning the growing exposure to
ionizing radiation (IR) originating from atrificial sources, especially from medical ones, and …

Spermatogenesis is a complex developmental process. During this process, male germ cells
from spermatogonia to sperm cells encounter a number of DNA damages. The most severe …

Objective To review the discovery of chromothripsis and analyze its impact on human
reproduction. Design Database and literature analysis. Setting University hospital. Patient …

Simple Summary Spermatogenesis is one of the most important processes for the
propagation of life; however, the testes' ability to form sperm via this differentiation process is …