This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

Making inferences about the computations performed by neuronal circuits from synapse-
level connectivity maps is an emerging opportunity in neuroscience. The mushroom body …

Understanding memory formation, storage and retrieval requires knowledge of the
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …

We define the chemoconnectome (CCT) as the entire set of neurotransmitters,
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …

Plasticity in animal behaviour relies on the ability to integrate external and internal cues from
the changing environment and hence modulate activity in synaptic circuits of the brain. This …

Circadian clocks regulate much of behavior and physiology, but the mechanisms by which
they do so remain poorly understood. While cyclic gene expression is thought to underlie …

Our understanding of the molecular mechanisms underlying sleep homeostasis is limited.
We have taken a systematic approach to study neural signaling by the transmitter 5 …

Animal behavior is, on the one hand, controlled by neuronal circuits that integrate external
sensory stimuli and induce appropriate motor responses. On the other hand, stimulus …

Highlights•Complex regulation of sleep and wake is traced through mushroom body input
and outputs.•The central complex promotes sleep and mediates sleep-drive.• …