Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total
body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of …

Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation.
Inflammation is one common and effective physiological event that protects against various …

Iron is a critical metal for several vital biological processes. Most of the body's iron is bound
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …

Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD)
characterized by iron-dependent accumulation of lipid peroxides. It is morphologically and …

Background Thalassemia is an inherited hematological disorder categorized by a decrease
or absence of one or more of the globin chains synthesis. Beta‐thalassemia is caused by …

Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

Several minerals are required for life to exist. In animals, 7 elements (Ca, P, Mg, Na, K, Cl,
and S) are required to be present in the diet in fairly large amounts (grams to tens of grams …

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

Iron deficiency and iron deficiency anemia (IDA) are major public health problems
worldwide, especially in young women. Oral iron supplementation can be an effective …

In iron-depleted women without anemia, oral iron supplements induce an increase in serum
hepcidin (SHep) that persists for 24 hours, decreasing iron absorption from supplements …