Homologous recombination (HR) repair of DNA double-strand breaks (DSBs) is critical for
maintaining genomic integrity and stability. Defects in HR increase the risk of tumorigenesis …

In eukaryotic cells, the ubiquitin–proteasome system (UPS) plays a crucial role in selectively
breaking down specific proteins. The ability of the UPS to target proteins effectively and …

Prostate cancer is the leading cause of cancer-related mortality among men worldwide. In
particular, castration-resistant prostate cancer presents a formidable clinical challenge and …

Simple Summary Dpep is a novel cell-penetrating peptide that selectively promotes the
death of multiple tumor cell types in vitro and in vivo, and that is a potential therapeutic …

In the present study, we explored the potential of coumarin-based compounds, known for
their potent anticancer properties, by designing and synthesizing a novel category of 8 …

Extramammary Paget disease (EMPD) is a rare skin cancer that primarily affects older
individuals predominantly in areas with apocrine sweat glands. Although most early EMPD …

Background Breast cancer is one of the most common malignant tumors in women. Cell
division cycle associated 5 (CDCA5), a master regulator of sister chromatid cohesion, was …

Multiple myeloma is a hematological malignancy that has evolved from antibody-secreting B
lymphocytes. Like other types of cancers, myeloma cells have acquired functional …

The global incidence of bladder cancer is more than half a million diagnoses each year.
Bladder cancer can be categorized into non-muscle-invasive bladder cancer (NMIBC) …

Ewing sarcoma (EwS), a highly aggressive malignancy affecting children and young adults,
is primarily driven by a distinctive oncogenic fusion, the EWSR1‐ETS, whose activity is a key …