[HTML][HTML] RNA methylation, homologous recombination repair and therapeutic resistance
Y Bai, H Zhao, H Liu, W Wang, H Dong… - Biomedicine & …, 2023 - Elsevier
Homologous recombination (HR) repair of DNA double-strand breaks (DSBs) is critical for
maintaining genomic integrity and stability. Defects in HR increase the risk of tumorigenesis …
maintaining genomic integrity and stability. Defects in HR increase the risk of tumorigenesis …
Potential of the nanoplatform and PROTAC interface to achieve targeted protein degradation through the Ubiquitin–Proteasome system
H Xie, C Zhang - European Journal of Medicinal Chemistry, 2024 - Elsevier
In eukaryotic cells, the ubiquitin–proteasome system (UPS) plays a crucial role in selectively
breaking down specific proteins. The ability of the UPS to target proteins effectively and …
breaking down specific proteins. The ability of the UPS to target proteins effectively and …
Oncogenic role of FOXM1 in human prostate cancer
DY Lee, JN Chun, I So, JH Jeon - Oncology Reports, 2023 - spandidos-publications.com
Prostate cancer is the leading cause of cancer-related mortality among men worldwide. In
particular, castration-resistant prostate cancer presents a formidable clinical challenge and …
particular, castration-resistant prostate cancer presents a formidable clinical challenge and …
Dpep Inhibits Cancer Cell Growth and Survival via Shared and Context-Dependent Transcriptome Perturbations
Q Zhou, LA Greene - Cancers, 2023 - mdpi.com
Simple Summary Dpep is a novel cell-penetrating peptide that selectively promotes the
death of multiple tumor cell types in vitro and in vivo, and that is a potential therapeutic …
death of multiple tumor cell types in vitro and in vivo, and that is a potential therapeutic …
Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization
A Alzamami, EM Radwan, E Abo-Elabass, ME Behery… - BMC chemistry, 2023 - Springer
In the present study, we explored the potential of coumarin-based compounds, known for
their potent anticancer properties, by designing and synthesizing a novel category of 8 …
their potent anticancer properties, by designing and synthesizing a novel category of 8 …
FOXM1: a new therapeutic target of extramammary Paget disease
T Ito, Y Tanaka, Y Kaku-Ito, Y Oda, T Nakahara - Scientific reports, 2024 - nature.com
Extramammary Paget disease (EMPD) is a rare skin cancer that primarily affects older
individuals predominantly in areas with apocrine sweat glands. Although most early EMPD …
individuals predominantly in areas with apocrine sweat glands. Although most early EMPD …
CDCA5 accelerates progression of breast cancer by promoting the binding of E2F1 and FOXM1
Y Xiong, L Shi, L Li, W Yang, H Zhang, X Zhao… - Journal of Translational …, 2024 - Springer
Background Breast cancer is one of the most common malignant tumors in women. Cell
division cycle associated 5 (CDCA5), a master regulator of sister chromatid cohesion, was …
division cycle associated 5 (CDCA5), a master regulator of sister chromatid cohesion, was …
[HTML][HTML] Targeting myeloma metabolism: How abnormal metabolism contributes to multiple myeloma progression and resistance to proteasome inhibitors
X Zhou, R He, WX Hu, S Luo, J Hu - Neoplasia, 2024 - Elsevier
Multiple myeloma is a hematological malignancy that has evolved from antibody-secreting B
lymphocytes. Like other types of cancers, myeloma cells have acquired functional …
lymphocytes. Like other types of cancers, myeloma cells have acquired functional …
Molecular biomarkers of progression in non-muscle-invasive bladder cancer—beyond conventional risk stratification
M Olislagers, FC de Jong, VC Rutten… - Nature Reviews …, 2024 - nature.com
The global incidence of bladder cancer is more than half a million diagnoses each year.
Bladder cancer can be categorized into non-muscle-invasive bladder cancer (NMIBC) …
Bladder cancer can be categorized into non-muscle-invasive bladder cancer (NMIBC) …
CD99 contributes to the EWS:: FLI1 transcriptome by specifically affecting FOXM1‐targets involved in the G2/M cell cycle phase, thus influencing the Ewing sarcoma …
M Pasello, MA Laginestra, MC Manara… - Journal of Cell …, 2024 - Wiley Online Library
Ewing sarcoma (EwS), a highly aggressive malignancy affecting children and young adults,
is primarily driven by a distinctive oncogenic fusion, the EWSR1‐ETS, whose activity is a key …
is primarily driven by a distinctive oncogenic fusion, the EWSR1‐ETS, whose activity is a key …