Mitochondrial β-oxidation of fatty acids generates acetyl-coA, NADH and FADH 2. Acyl-coA
synthetases catalyze the binding of fatty acids to coenzyme A to form fatty acyl-coA …

Adenylate/uridylate-rich elements (AREs) are found in the 3′ untranslated region (UTR) of
many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription …

Finding the components of cellular circuits and determining their functions systematically
remains a major challenge in mammalian cells. Here, we introduced genome-wide pooled …

RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two
complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a …

An important mechanism of posttranscriptional gene regulation in mammalian cells is the
rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in …

The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay
rates influence gene expression. mRNA stability influences gene expression in virtually all …

The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted
for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated …

An important paradigm for post‐transcriptional regulation is the control of cytoplasmic mRNA
stability mediated by AU‐rich elements (AREs) in the 3′ untranslated region of transcripts …