Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …

Rheumatic heart valve disease (RHVD) is a post-infectious sequel of acute rheumatic fever
resulting from an abnormal immune response to a streptococcal pharyngitis that triggers …

The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …

Tumors are equipped with a highly complex machinery of interrelated events so as to adapt
to hazardous conditions, preserve a growing cell mass and thrive at the site of metastasis …

Cancer immunotherapy can be augmented with toll-like receptor agonist (TLRa) adjuvants,
which interact with immune cells to elicit potent immune activation. Despite their potential …

Triple negative breast cancer (TNBC) is a significant clinical problem to which
immunotherapeutic strategies have been applied with limited success. Using the syngeneic …

Lymphatic vessels provide an anatomical framework for immune surveillance and adaptive
immune responses. Although appreciated as the route for Ag and dendritic cell transport …

Revealing the mechanisms that underlie the expansion of antitumor CD8+ T cells that are
associated with improved clinical outcomes is critical to improving immunotherapeutic …

We derive the homogenized governing equations for a double porosity system where the
fluid flow within the individual compartments is governed by the coupling between the Darcy …

The deployment of imaging examinations has evolved into a robust approach for the
diagnosis of lymph node metastasis (LNM). The advancement of technology, coupled with …