The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration

TH Hutson, S Di Giovanni - Nature Reviews Neurology, 2019 - nature.com
Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

Transcutaneous spinal cord stimulation and motor rehabilitation in spinal cord injury: a systematic review

A Megía García, D Serrano-Muñoz… - … and neural repair, 2020 - journals.sagepub.com
Background. Epidural spinal electrical stimulation at the lumbar spinal level evokes rhythmic
muscle activation of lower-limb antagonists, attributed to the central pattern generator …

Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia

ML Gill, PJ Grahn, JS Calvert, MB Linde, IA Lavrov… - Nature medicine, 2018 - nature.com
Spinal sensorimotor networks that are functionally disconnected from the brain because of
spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore …

Epidural spinal cord stimulation facilitates immediate restoration of dormant motor and autonomic supraspinal pathways after chronic neurologically complete spinal …

D Darrow, D Balser, TI Netoff, A Krassioukov… - Journal of …, 2019 - liebertpub.com
Abstract Epidural Spinal Cord Stimulation (eSCS) in combination with extensive
rehabilitation has been reported to restore volitional movement in a select group of subjects …

Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury

HJ Jo, MA Perez - Brain, 2020 - academic.oup.com
Rehabilitative exercise in humans with spinal cord injury aims to engage residual neural
networks to improve functional recovery. We hypothesized that exercise combined with non …

Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury

PG Nagappan, H Chen, DY Wang - Military Medical Research, 2020 - Springer
Neuronal networks, especially those in the central nervous system (CNS), evolved to
support extensive functional capabilities while ensuring stability. Several physiological …

Transcutaneous spinal cord stimulation and motor responses in individuals with spinal cord injury: A methodological review

C Taylor, C McHugh, D Mockler, C Minogue… - PLoS …, 2021 - journals.plos.org
Background Transcutaneous spinal cord stimulation (tSCS) is a non-invasive modality in
which electrodes can stimulate spinal circuitries and facilitate a motor response. This review …

Trunk stability enabled by noninvasive spinal electrical stimulation after spinal cord injury

M Rath, AH Vette, S Ramasubramaniam, K Li… - Journal of …, 2018 - liebertpub.com
Electrical neuromodulation of spinal networks improves the control of movement of the
paralyzed limbs after spinal cord injury (SCI). However, the potential of noninvasive spinal …

Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury

B Brommer, M He, Z Zhang, Z Yang, JC Page… - Nature …, 2021 - nature.com
After complete spinal cord injuries (SCI), spinal segments below the lesion maintain inter-
segmental communication via the intraspinal propriospinal network. However, it is unknown …

[HTML][HTML] Epidural electrical stimulation for spinal cord injury

EH Choi, S Gattas, NJ Brown, JD Hong… - Neural Regeneration …, 2021 - journals.lww.com
A long-standing goal of spinal cord injury research is to develop effective repair strategies,
which can restore motor and sensory functions to near-normal levels. Recent advances in …