Multiple Sclerosis (MS) is traditionally considered an autoimmune-mediated demyelinating
disease, the pathoetiology of which is unknown. However, the key question remains whether …

In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules
and are consequently involved in disease progression. We have investigated the proteomic …

There is an increasing number of neurologic disorders found to be associated with loss
and/or dysfunction of the CNS myelin sheath, ranging from the classic demyelinating …

Central nervous system B cells have several potential roles in multiple sclerosis (MS):
secretors of proinflammatory cytokines and chemokines, presenters of autoantigens to T …

Myelin-reactive T cells have been identified in patients with multiple sclerosis (MS) and
healthy subjects with comparable frequencies, but the contribution of these autoreactive T …

The placenta is one of the organs with the highest evolutionary diversity among animal
species. In consequence, an animal model that reflects human placentation exactly does not …

Background MicroRNAs have emerged as an important class of modulators of gene
expression. These molecules influence protein synthesis through translational repression or …

Macrophages are a heterogeneous cell population playing a pivotal role in tissue
homeostasis and inflammation, and their phenotype strongly depends on the micromilieu …

A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-
lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical …

Multiple sclerosis (MS) is characterized by inflammatory insults that drive neuroaxonal injury.
However, knowledge about neuron-intrinsic responses to inflammation is limited. By …