US FDA approved drugs from 2015–June 2020: a perspective
In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods
Sex hormones have been implicated in neurite outgrowth, synaptogenesis, dendritic
branching, myelination and other important mechanisms of neural plasticity. Here we review …
branching, myelination and other important mechanisms of neural plasticity. Here we review …
Pulmonary neuroendocrine cells amplify allergic asthma responses
INTRODUCTION The lung, with its vast surface area, senses and responds to signals in
inhaled air. Aberrant interactions between the lung and the environment underlie many …
inhaled air. Aberrant interactions between the lung and the environment underlie many …
Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder
AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …
Subunit composition, distribution and function of GABA-A receptor subtypes
W Sieghart, G Sperk - Current topics in medicinal chemistry, 2002 - ingentaconnect.com
GABA-A receptors are the major inhibitory neurotransmitter receptors in the brain and are
the site of action of many clinically important drugs. These receptors are composed of five …
the site of action of many clinically important drugs. These receptors are composed of five …
Electrophysiology of ionotropic GABA receptors
E Sallard, D Letourneur, P Legendre - Cellular and Molecular Life …, 2021 - Springer
GABAA receptors are ligand-gated chloride channels and ionotropic receptors of GABA, the
main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and …
main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and …
Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels
F Hyder, DL Rothman… - Proceedings of the …, 2013 - National Acad Sciences
The continuous need for ion gradient restoration across the cell membrane, a prerequisite
for synaptic transmission and conduction, is believed to be a major factor for brain's high …
for synaptic transmission and conduction, is believed to be a major factor for brain's high …
Structure and subunit composition of GABAA receptors
W Sieghart, K Fuchs, V Tretter, V Ebert… - Neurochemistry …, 1999 - Elsevier
GABAA receptors are the major inhibitory neurotransmitter receptors in the brain and are the
site of action of many clinically important drugs. These receptors are composed of five …
site of action of many clinically important drugs. These receptors are composed of five …
GABAB receptors
DIB Kerr, J Ong - Pharmacology & therapeutics, 1995 - Elsevier
GABAB receptors are a distinct subclass of receptors for the major inhibitory transmitter 4-
aminobutanoic acid (GABA) that mediate depression of synaptic transmission and contribute …
aminobutanoic acid (GABA) that mediate depression of synaptic transmission and contribute …
Role of GABAA Receptors in the Regulation of Sleep: Initial Sleep Responses to Peripherally Administered Modulators and Agonists
M Lancel - Sleep, 1999 - academic.oup.com
This paper reviews the sleep effects of systemically administered agonistic modulators of
GABAA receptors, including barbiturates, benzodiazepines, zolpidem, zopiclone and …
GABAA receptors, including barbiturates, benzodiazepines, zolpidem, zopiclone and …