Instability challenges and stabilization strategies of pharmaceutical proteins

M Akbarian, SH Chen - Pharmaceutics, 2022 - mdpi.com
Maintaining the structure of protein and peptide drugs has become one of the most important
goals of scientists in recent decades. Cold and thermal denaturation conditions …

New frontiers in monoclonal antibodies for the targeted therapy of acute myeloid leukemia and myelodysplastic syndromes

M Gallazzi, MAM Ucciero, DG Faraci… - International Journal of …, 2022 - mdpi.com
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) represent an unmet
clinical need whose prognosis is still dismal. Alterations of immune response play a …

CD123 a therapeutic target for acute myeloid leukemia and blastic plasmocytoid dendritic neoplasm

E Pelosi, G Castelli, U Testa - International Journal of Molecular Sciences, 2023 - mdpi.com
In spite of consistent progress at the level of basic research and of clinical treatment, acute
myeloid leukemia (AML) still represents an unmet clinical need for adult and pediatric …

Mixed-phenotype acute leukemia: clinical diagnosis and therapeutic strategies

BS George, B Yohannan, A Gonzalez, A Rios - Biomedicines, 2022 - mdpi.com
Mixed-phenotype acute leukemia (MPAL) comprises a heterogenous group of leukemias
that are genetically, immunophenotypically, and clinically, diverse. Given the rarity of the …

[HTML][HTML] Immunotherapy in leukaemia: Immunotherapy in leukaemia

X Mu, C Chen, L Dong, Z Kang, Z Sun… - Acta biochimica et …, 2023 - ncbi.nlm.nih.gov
Leukaemia is the common name for a group of malignant diseases of the haematopoietic
system with complex classifications and characteristics. Remarkable progress has been …

Development and characterization of an anti-cancer monoclonal antibody for treatment of human carcinomas

K Tsang, M Fantini, SA Mavroukakis, A Zaki… - Cancers, 2022 - mdpi.com
Simple Summary Cancers can grow and spread to different parts of the body. The aim of
immunotherapy is to stimulate the immune system to eliminate cancer cells in a selective …

The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells

M Bianchi, C Reichen, A Croset, S Fischer… - Cancer immunology …, 2024 - AACR
The prognosis of patients with acute myeloid leukemia (AML) is limited, especially for elderly
or unfit patients not eligible for hematopoietic stem cell (HSC) transplantation. The disease is …

Editorial to the Special Issue “Recent Advances in Biochemical Mechanisms of Acute Myeloid Leukemia”

M Mesuraca, C Nisticò, E Chiarella - Biomedicines, 2023 - mdpi.com
Acute myeloid leukemia (AML) is a clonal malignant disorder of myeloid progenitor cells
characterized by uncontrolled proliferation, dysregulation in the differentiation program, and …

[PDF][PDF] With a little help from a friend: enhancing immunotherapy in acute myeloid leukemia

A Marcinek - 2023 - edoc.ub.uni-muenchen.de
Acute myeloid leukemia (AML) is the most common acute leukemia in the adult population. It
is characterized by the high proliferation of undifferentiated hematopoietic cells, which …

[PDF][PDF] The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells

A Goubier, MP AG - scholar.archive.org
The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T
Cell–Mediated Killing of AML Leukemic Stem Ce Page 1 source: https://doi.org/10.48350/196383 …