[HTML][HTML] Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation
Y Lu, Z Li, S Zhang, T Zhang, Y Liu, L Zhang - Theranostics, 2023 - ncbi.nlm.nih.gov
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …
through an autophagy mechanism, thus maintaining mitochondria and intracellular …
Role of AMPK mediated pathways in autophagy and aging
Y Ge, M Zhou, C Chen, X Wu, X Wang - Biochimie, 2022 - Elsevier
AMPK is an important kinase regulating energy homeostasis and also a key protein involved
in a variety of signal transduction pathways. It plays a vitally regulatory role in cellular …
in a variety of signal transduction pathways. It plays a vitally regulatory role in cellular …
[HTML][HTML] Promising drug targets and associated therapeutic interventions in Parkinson's disease
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …
availability of symptomatic treatments, response towards the health of PD patients remains …
Role of ubiquitin–proteasome and autophagy-lysosome pathways in α-synuclein aggregate clearance
Synuclein aggregation in neuronal cells is the primary underlying cause of
synucleinopathies. Changes in gene expression patterns, structural modifications, and …
synucleinopathies. Changes in gene expression patterns, structural modifications, and …
[HTML][HTML] The role of c-Abl tyrosine Kinase in brain and its pathologies
H Motaln, B Rogelj - Cells, 2023 - mdpi.com
Differentiated status, low regenerative capacity and complex signaling make neuronal
tissues highly susceptible to translating an imbalance in cell homeostasis into cell death …
tissues highly susceptible to translating an imbalance in cell homeostasis into cell death …
[HTML][HTML] The multiple roles of autophagy in neural function and diseases
Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,
where proteins, lipids, and organelles are degraded and recycled. According to the way the …
where proteins, lipids, and organelles are degraded and recycled. According to the way the …
[HTML][HTML] Changes in Drp1 function and mitochondrial morphology are associated with the α-synuclein pathology in a transgenic mouse model of Parkinson's disease
Alterations in mitochondrial function and morphology are associated with many human
diseases, including cancer and neurodegenerative diseases. Mitochondrial impairment is …
diseases, including cancer and neurodegenerative diseases. Mitochondrial impairment is …
[HTML][HTML] HMGB1 in nervous system diseases: A common biomarker and potential therapeutic target
D Mao, Y Zheng, F Xu, X Han, H Zhao - Frontiers in Neurology, 2022 - frontiersin.org
High-mobility group box-1 (HMGB1) is a nuclear protein associated with early inflammatory
changes upon extracellular secretion expressed in various cells, including neurons and …
changes upon extracellular secretion expressed in various cells, including neurons and …
Association of p53 with neurodegeneration in Parkinson's disease
Q Luo, W Sun, YF Wang, J Li, DW Li - Parkinson's Disease, 2022 - Wiley Online Library
p53 is a vital transcriptional protein implicated in regulating diverse cellular processes,
including cell cycle arrest, DNA repair, mitochondrial metabolism, redox homeostasis …
including cell cycle arrest, DNA repair, mitochondrial metabolism, redox homeostasis …
[HTML][HTML] Clinically precedented protein kinases: Rationale for their use in neurodegenerative disease
CL Benn, LA Dawson - Frontiers in Aging Neuroscience, 2020 - frontiersin.org
Kinases are an intensively studied drug target class in current pharmacological research as
evidenced by the large number of kinase inhibitors being assessed in clinical trials. Kinase …
evidenced by the large number of kinase inhibitors being assessed in clinical trials. Kinase …