In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the
younger population. Effective treatment is crucial for improving patients' survival outcomes …

COPD is predicted to become the third leading cause of morbidity and mortality worldwide
by 2030. Cigarette smoking (active or passive) is one of its chief causes, with about 20% of …

Intracellular lipopolysaccharide (LPS) sensing by the noncanonical inflammasome
comprising caspase-4 or-11 governs antibacterial host defense. How LPS gains intracellular …

Ischemic stroke (IS) is one of the leading causes of death and disability. Its pathogenesis is
not completely clear, and inflammatory cascade is one of its main pathological processes …

Endotoxin—bacterial lipopolysaccharide (LPS)—is a driver of lethal infection sepsis through
excessive activation of innate immune responses. When delivered to the cytosol of …

Pyroptosis is closely involved in the pathopoiesis of cerebral ischemia and reperfusion (I/R)
injury which seriously dangers human's life. Studies report that tangeretin (TANG), which is …

Programmed cell death (PCD) is an essential mechanism of antimicrobial defense. Recent
work has revealed an unexpected diversity in the types of PCD elicited during infection, as …

About thirty years ago, a new form of pro-inflammatory lytic cell death was observed and
termed pyroptosis. Only in 2015, gasdermins were defined as molecules that create pores at …

As a potent clinical strategy, cancer therapy has sparked an academic boom over the past
few years. Immune checkpoint inhibitors (ICIs) have been demonstrated to be highly …

Background Cervical cancer, a pernicious gynecological malignancy, causes the mortality of
hundreds of thousands of females worldwide. Despite a considerable decline in mortality …