Vaccines for the 21st century
I Delany, R Rappuoli, E De Gregorio - EMBO molecular medicine, 2014 - embopress.org
In the last century, vaccination has been the most effective medical intervention to reduce
death and morbidity caused by infectious diseases. It is believed that vaccines save at least …
death and morbidity caused by infectious diseases. It is believed that vaccines save at least …
Challenges on the development of a dengue vaccine: a comprehensive review of the state of the art
J Pintado Silva… - Journal of General …, 2023 - microbiologyresearch.org
Dengue virus (DENV) is the mosquito-borne virus of greatest human health concern. There
are four serotypes of DENV (1-4) that co-circulate in endemic areas. Each serotype of DENV …
are four serotypes of DENV (1-4) that co-circulate in endemic areas. Each serotype of DENV …
Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells
D Weiskopf, MA Angelo… - Proceedings of the …, 2013 - National Acad Sciences
The role of CD8+ T cells in dengue virus infection and subsequent disease manifestations is
not fully understood. According to the original antigenic sin theory, skewing of T-cell …
not fully understood. According to the original antigenic sin theory, skewing of T-cell …
Structural biology of Zika virus and other flaviviruses
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional
similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) …
similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) …
Current trends and limitations in dengue antiviral research
JO Obi, H Gutiérrez-Barbosa, JV Chua… - Tropical Medicine and …, 2021 - mdpi.com
Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …
approximately 2.5 billion people living in over 100 countries. Increasing geographic …
Dengue virus
A Murugesan, M Manoharan - Emerging and reemerging viral pathogens, 2020 - Elsevier
Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-
stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus …
stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus …
Flaviviridae Viruses and Oxidative Stress: Implications for Viral Pathogenesis
Z Zhang, L Rong, YP Li - Oxidative medicine and cellular …, 2019 - Wiley Online Library
Oxidative stress is induced once the balance of generation and neutralization of reactive
oxygen species (ROS) is broken in the cell, and it plays crucial roles in a variety of natural …
oxygen species (ROS) is broken in the cell, and it plays crucial roles in a variety of natural …
Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus
CA Daep, JL Muñoz-Jordán, EA Eugenin - Journal of neurovirology, 2014 - Springer
Abstract The flaviviruses dengue, West Nile, and Japanese encephalitis represent three
major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of …
major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of …
Molecular mechanisms of antiviral agents against dengue virus
Dengue is a major global health threat causing 390 million dengue infections and 25,000
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …
Inactivated viral vaccines
B Sanders, M Koldijk, H Schuitemaker - Vaccine analysis: strategies …, 2015 - Springer
Inactivated vaccines have been used for over a century to induce protection against viral
pathogens. This established approach of vaccine production is relatively straightforward to …
pathogens. This established approach of vaccine production is relatively straightforward to …