In the last century, vaccination has been the most effective medical intervention to reduce
death and morbidity caused by infectious diseases. It is believed that vaccines save at least …

Dengue virus (DENV) is the mosquito-borne virus of greatest human health concern. There
are four serotypes of DENV (1-4) that co-circulate in endemic areas. Each serotype of DENV …

The role of CD8+ T cells in dengue virus infection and subsequent disease manifestations is
not fully understood. According to the original antigenic sin theory, skewing of T-cell …

Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional
similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) …

Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …

Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-
stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus …

Oxidative stress is induced once the balance of generation and neutralization of reactive
oxygen species (ROS) is broken in the cell, and it plays crucial roles in a variety of natural …

Abstract The flaviviruses dengue, West Nile, and Japanese encephalitis represent three
major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of …

Dengue is a major global health threat causing 390 million dengue infections and 25,000
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …

Inactivated vaccines have been used for over a century to induce protection against viral
pathogens. This established approach of vaccine production is relatively straightforward to …