SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism

M Packer - Nature Reviews Cardiology, 2023 - nature.com
Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by
direct action on the failing heart that is independent of changes in renal tubular function. In …

The role of CD36 in cardiovascular disease

H Shu, Y Peng, W Hang, J Nie, N Zhou… - Cardiovascular …, 2022 - academic.oup.com
CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely
expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty …

Cardiac lipid metabolism, mitochondrial function, and heart failure

L Da Dalt, AG Cabodevilla, IJ Goldberg… - Cardiovascular …, 2023 - academic.oup.com
A fine balance between uptake, storage, and the use of high energy fuels, like lipids, is
crucial in the homeostasis of different metabolic tissues. Nowhere is this balance more …

Vasculoprotective effects of ginger (Zingiber officinale Roscoe) and underlying molecular mechanisms

C Li, J Li, F Jiang, NT Tzvetkov, JO Horbanczuk, Y Li… - Food & function, 2021 - pubs.rsc.org
Ginger (Zingiber officinale Roscoe) is a common and widely used spice. It is rich in various
chemical constituents, including phenolic compounds, terpenes, polysaccharides, lipids …

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

X Liu, X Xu, T Zhang, L Xu, H Tao, Y Liu… - Phytotherapy …, 2023 - Wiley Online Library
Cardiovascular diseases are currently the primary cause of mortality in the whole world.
Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are …

Meteorin-like protein (METRNL)/IL-41 improves LPS-induced inflammatory responses via AMPK or PPARδ–mediated signaling pathways

TW Jung, DH Pyun, TJ Kim, HJ Lee, ES Park… - Advances in Medical …, 2021 - Elsevier
Purpose Meteorin-like protein (METRNL)(also known as IL-41), recently identified as a
myokine, is released in response to muscle contraction. It improves the skeletal muscle …

Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage

A Thiele, K Luettges, D Ritter, N Beyhoff… - Cardiovascular …, 2022 - academic.oup.com
Aims Heart failure (HF) is characterized by an overactivation of β-adrenergic signalling that
directly contributes to impairment of myocardial function. Moreover, β-adrenergic …

[HTML][HTML] Chronic exposure to low-dose cadmium facilitated nonalcoholic steatohepatitis in mice by suppressing fatty acid desaturation

Y Zhu, Y Zhao, XX Chai, J Zhou, MJ Shi, Y Zhao… - Ecotoxicology and …, 2022 - Elsevier
Exposure to cadmium (Cd), a toxic metal, is epidemiologically linked to nonalcoholic
steatohepatitis (NASH) in humans. However, the role of Cd in NASH remains to be fully …

Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling

Z Meng, Q Liu, F Sun, L Qiao - Lipids in Health and Disease, 2019 - Springer
Background Steatosis is an important clinical manifestation associated with chronic hepatitis
C virus (HCV) infection. AMP-activated protein kinase (AMPK), a major mediator of lipid …

[HTML][HTML] The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK

T Zhang, L Xu, X Guo, H Tao, Y Liu, X Liu… - Journal of …, 2023 - Elsevier
Heart failure (HF) is a highly morbid syndrome that seriously affects the physical and mental
health of patients and generates an enormous socio-economic burden. In addition to cardiac …