[HTML][HTML] Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease
T Yin, Y Liu, W Ji, J Zhuang, X Chen, B Gong, J Chu… - Theranostics, 2023 - ncbi.nlm.nih.gov
With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …
also increasing. According to current estimates, approximately 11% of people over 65 suffer …
Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine
Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in
intracellular communication through EV-encapsulated informative content, including …
intracellular communication through EV-encapsulated informative content, including …
[HTML][HTML] Intranasal delivery of BDNF-loaded small extracellular vesicles for cerebral ischemia therapy
X Zhou, X Deng, M Liu, M He, W Long, Z Xu… - Journal of Controlled …, 2023 - Elsevier
Mesenchymal stem cells (MSCs) have shown promise for the therapy of cerebral ischemia in
animal studies and clinical trials, yet their clinical application still faces many challenges …
animal studies and clinical trials, yet their clinical application still faces many challenges …
[HTML][HTML] HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of …
Q Wang, L Zhang, Z Sun, B Chi, A Zou, L Mao… - Materials Today Bio, 2021 - Elsevier
Aims Naturally secreted extracellular vesicles (EVs) play important roles in stem-mediated
cardioprotection. This study aimed to investigate the cardioprotective function and …
cardioprotection. This study aimed to investigate the cardioprotective function and …
Paracrine effects of mesenchymal stem cells in ischemic stroke: Opportunities and challenges
It is well acknowledged that neuroprotective effects of transplanted mesenchymal stem cells
(MSCs) in ischemic stroke are attributed to their paracrine-mediated actions or bystander …
(MSCs) in ischemic stroke are attributed to their paracrine-mediated actions or bystander …
Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?
J Isaković, K Šerer, B Barišić, D Mitrečić - Frontiers in bioengineering …, 2023 - frontiersin.org
Neurological disorders are recognized as major causes of death and disability worldwide.
Because of this, they represent one of the largest public health challenges. With awareness …
Because of this, they represent one of the largest public health challenges. With awareness …
Probing multiple transplant delivery routes of CD+ 34 stem cells for promoting behavioral and histological benefits in experimental ischemic stroke
JY Lee, J Cho, F D'Egidio, C Vignon… - Stem Cells …, 2024 - academic.oup.com
Stroke is a leading cause of death in the US and around the world but with limited treatment
options. Survivors often present with long-term cognitive and neurological deficits. Stem cell …
options. Survivors often present with long-term cognitive and neurological deficits. Stem cell …
Stem cells: innovative therapeutic options for neurodegenerative diseases?
G Bonaventura, A Munafò, CM Bellanca, V La Cognata… - Cells, 2021 - mdpi.com
Neurodegenerative diseases are characterized by the progressive loss of structure and/or
function of both neurons and glial cells, leading to different degrees of pathology and loss of …
function of both neurons and glial cells, leading to different degrees of pathology and loss of …
Stem cell-and cell-based therapies for ischemic stroke
DC Nistor-Cseppentö, MC Jurcău, A Jurcău… - Bioengineering, 2022 - mdpi.com
Stroke is the second cause of disability worldwide as it is expected to increase its incidence
and prevalence. Despite efforts to increase the number of patients eligible for recanalization …
and prevalence. Despite efforts to increase the number of patients eligible for recanalization …
Mesenchymal stromal cells in ischemic brain injury
B Brooks, D Ebedes, A Usmani, JV Gonzales-Portillo… - Cells, 2022 - mdpi.com
Ischemic brain injury represents a major cause of death worldwide with limited treatment
options with a narrow therapeutic window. Accordingly, novel treatments that extend the …
options with a narrow therapeutic window. Accordingly, novel treatments that extend the …