All eukaryotic cells, including oocytes, utilize an engine called cyclin-dependent kinase
(Cdk) to drive the cell cycle. Cdks are activated by a co-factor called cyclin, which regulates …

The oocyte must grow and mature before fertilization, thanks to a close dialogue with the
somatic cells that surround it. Part of this communication is through filopodia-like protrusions …

To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II
until sperm entry. Emi2 is essential to keep oocytes arrested until fertilization. However, how …

Progression through the mitotic and meiotic cell cycle is driven by fluctuations in the levels of
cyclins, the regulatory subunits controlling the localization and activity of CDK1 kinases …

The generation of mature and healthy oocytes is the most critical event in the entire female
reproductive process, and the mechanisms regulating this process remain to be studied …

Background: Cyclin B1 and cyclin B2 are key regulators of cell cycle progression and have
been implicated in the prognostic significance of various cancers. This meta-analysis aimed …

Before fertilization, ovulated mammalian oocytes are arrested at the metaphase of second
meiosis (MII), which is maintained by the so-called cytostatic factor (CSF). It is well known …

Background Triploidy is one of the most common chromosome abnormalities affecting
human gestation and accounts for an important fraction of first-trimester miscarriages …

Tetrodotoxin (TTX) is a deadly neurotoxin and usually accumulates in large amounts in the
ovaries but is non-toxic or low toxic in the testis of pufferfish. The molecular mechanism …

Cyclins and related cyclin-dependent kinases play vital roles in regulating the progression in
the cell cycle. Understanding the intrinsic mechanisms of cyclins promises knowledge about …