[HTML][HTML] Cholesterol metabolic reprogramming in cancer and its pharmacological modulation as therapeutic strategy
I Giacomini, F Gianfanti, MA Desbats, G Orso… - Frontiers in …, 2021 - frontiersin.org
Cholesterol is a ubiquitous sterol with many biological functions, which are crucial for proper
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …
Iron: an essential element of cancer metabolism
MY Hsu, E Mina, A Roetto, PE Porporato - Cells, 2020 - mdpi.com
Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in
a hostile environment characterized by nutrient deprivation, poor vascularization and …
a hostile environment characterized by nutrient deprivation, poor vascularization and …
LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies
Cholesterol is essential for a variety of functions in endocrine-related cells, including
hormone and steroid production. We have reviewed the progress to date in research on the …
hormone and steroid production. We have reviewed the progress to date in research on the …
Anticancer properties of lobetyolin, an essential component of Radix Codonopsis (Dangshen)
C Bailly - Natural products and bioprospecting, 2021 - Springer
Lobetyolin (LBT) is a polyacetylene glycoside found in diverse medicinal plants but mainly
isolated from the roots of Codonopsis pilosula, known as Radix Codonopsis or Dangshen …
isolated from the roots of Codonopsis pilosula, known as Radix Codonopsis or Dangshen …
Exosomes co‐expressing AQP5‐targeting miRNAs and IL‐4 receptor‐binding peptide inhibit the migration of human breast cancer cells
EJ Park, HJ Jung, HJ Choi, HJ Jang, HJ Park… - The FASEB …, 2020 - Wiley Online Library
Abstract Aquaporin‐5 (AQP5) plays a role in breast cancer cell migration. This study aimed
to identify AQP5‐targeting miRNAs and examine their effects on breast cancer cell migration …
to identify AQP5‐targeting miRNAs and examine their effects on breast cancer cell migration …
Targeting the redox landscape in cancer therapy
D Narayanan, S Ma, D Özcelik - Cancers, 2020 - mdpi.com
Reactive oxygen species (ROS) are produced predominantly by the mitochondrial electron
transport chain and by NADPH oxidases in peroxisomes and in the endoplasmic reticulum …
transport chain and by NADPH oxidases in peroxisomes and in the endoplasmic reticulum …
The double faced role of xanthine oxidoreductase in cancer
M Chen, L Meng - Acta Pharmacologica Sinica, 2022 - nature.com
Xanthine oxidoreductase (XOR) is a critical, rate-limiting enzyme that controls the last two
steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid …
steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid …
AQP3 and AQP5—potential regulators of redox status in breast cancer
L Milković, A Čipak Gašparović - Molecules, 2021 - mdpi.com
Breast cancer is still one of the leading causes of mortality in the female population. Despite
the campaigns for early detection, the improvement in procedures and treatment, drastic …
the campaigns for early detection, the improvement in procedures and treatment, drastic …
Computational screening for the anticancer potential of seed-derived antioxidant peptides: A cheminformatic approach
Some seed-derived antioxidant peptides are known to regulate cellular modulators of ROS
production, including those proposed to be promising targets of anticancer therapy …
production, including those proposed to be promising targets of anticancer therapy …
[HTML][HTML] Xanthine dehydrogenase rewires metabolism and the survival of nutrient deprived lung adenocarcinoma cells by facilitating UPR and autophagic degradation
M Chen, W Guo, S Chen, X Guo, L Xu… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Xanthine dehydrogenase (XDH) is the rate-limiting enzyme in purine catabolism by
converting hypoxanthine to xanthine and xanthine to uric acid. The altered expression and …
converting hypoxanthine to xanthine and xanthine to uric acid. The altered expression and …