Tumour progression is dependent on the interaction between tumour cells and cells of the
surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell …

When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …

Metastasis is the leading reason for the resultant mortality of patients with cancer. The past
few decades have witnessed remarkable progress in understanding the molecular and …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to
be the most significant problem in the field of cancer. Patients who present with metastatic …

The most common skeletal complication of breast cancer is osteolytic bone metastasis. Bone
metastases are present in 80% of patients with advanced disease and cause significant …

Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after
ischemic injury. Background Stem cell and leukocyte migration during homeostasis and …

To delineate the role of SDF‐1 and CXCR4 in metastatic prostate cancer (CaP), positive
correlations were established between SDF‐1 levels and tumor metastasis. Neutralization of …

Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide.
Despite sensitivity to androgen deprivation, patients with advanced disease eventually …

Advanced prostate cancer is frequently accompanied by the development of metastasis to
bone. In the past, prostate cancer bone metastases were characterized as being …