The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human
disease genes. Based on its physiological aging characteristics and superiority, the use of …

Aging is associated with age-related diseases and an increase susceptibility of cancer.
Dissecting the molecular mechanisms that underlie aging and longevity would contribute to …

We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …

The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …

N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD), one of the most common
additives used in rubber, enters the environment due to significant emissions of tire wear …

Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In
order to understand whether and how lysosomes alter with age and contribute to lifespan …

Living longer without simultaneously extending years spent in good health (“health span”) is
an increasing societal burden, demanding new therapeutic strategies. Hydrogen sulfide …

The T arget of R apamycin (TOR or mTOR) is a serine/threonine kinase that regulates
growth, development, and behaviors by modulating protein synthesis, autophagy, and …

Abstract Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the
transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan …

Background Little is known about the role of amino acids in cellular signaling pathways,
especially as it pertains to pathways that regulate the rate of aging. However, it has been …