Caenorhabditis elegans as a Useful Model for Studying Aging Mutations
S Zhang, F Li, T Zhou, G Wang, Z Li - Frontiers in endocrinology, 2020 - frontiersin.org
The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human
disease genes. Based on its physiological aging characteristics and superiority, the use of …
disease genes. Based on its physiological aging characteristics and superiority, the use of …
DAF-16/FOXO transcription factor in aging and longevity
X Sun, WD Chen, YD Wang - Frontiers in pharmacology, 2017 - frontiersin.org
Aging is associated with age-related diseases and an increase susceptibility of cancer.
Dissecting the molecular mechanisms that underlie aging and longevity would contribute to …
Dissecting the molecular mechanisms that underlie aging and longevity would contribute to …
[HTML][HTML] Molecular topography of an entire nervous system
We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …
Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression
R Kaletsky, V Yao, A Williams, AM Runnels… - PLoS …, 2018 - journals.plos.org
The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …
Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans
X Hua, D Wang - Environmental Science & Technology, 2023 - ACS Publications
N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD), one of the most common
additives used in rubber, enters the environment due to significant emissions of tire wear …
additives used in rubber, enters the environment due to significant emissions of tire wear …
Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans
Y Sun, M Li, D Zhao, X Li, C Yang, X Wang - Elife, 2020 - elifesciences.org
Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In
order to understand whether and how lysosomes alter with age and contribute to lifespan …
order to understand whether and how lysosomes alter with age and contribute to lifespan …
Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans
Living longer without simultaneously extending years spent in good health (“health span”) is
an increasing societal burden, demanding new therapeutic strategies. Hydrogen sulfide …
an increasing societal burden, demanding new therapeutic strategies. Hydrogen sulfide …
TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging
TK Blackwell, AK Sewell, Z Wu, M Han - Genetics, 2019 - academic.oup.com
The T arget of R apamycin (TOR or mTOR) is a serine/threonine kinase that regulates
growth, development, and behaviors by modulating protein synthesis, autophagy, and …
growth, development, and behaviors by modulating protein synthesis, autophagy, and …
Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
Abstract Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the
transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan …
transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan …
Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans
Background Little is known about the role of amino acids in cellular signaling pathways,
especially as it pertains to pathways that regulate the rate of aging. However, it has been …
especially as it pertains to pathways that regulate the rate of aging. However, it has been …