Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Sequence-based analysis and prediction are fundamental bioinformatic tasks that facilitate
understanding of the sequence (-structure)-function paradigm for DNAs, RNAs and proteins …

As a newly discovered protein posttranslational modification, histone lysine crotonylation
(Kcr) involved in cellular regulation and human diseases. Various proteomics technologies …

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.
Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies …

Highlights•Non-acetyl histone acylations are catalyzed by classical acetylation
modifiers.•Active site engagement of the acyl group determines acyl type-specific …

Lysine crotonylation has been discovered in histone and non-histone proteins and found to
be involved in diverse diseases and biological processes, such as neuropsychiatric disease …

Metabolites are intermediate products of cellular metabolism catalysed by various enzymes.
Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal …

Motivation As one of the most important post-translational modifications (PTMs), protein
lysine crotonylation (Kcr) has attracted wide attention, which involves in important …

Protein post-translational modifications play key roles in multiple cellular processes by
allowing rapid reprogramming of individual protein functions. Acylation, one of the most …