[HTML][HTML] Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation

M Xue, VW Yong - The Lancet Neurology, 2020 - thelancet.com
Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …

[HTML][HTML] APOE2: protective mechanism and therapeutic implications for Alzheimer's disease

Z Li, F Shue, N Zhao, M Shinohara, G Bu - Molecular neurodegeneration, 2020 - Springer
Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Canadian stroke best practice recommendations: Management of Spontaneous Intracerebral Hemorrhage, 7th Edition Update 2020

A Shoamanesh, M Patrice Lindsay… - … journal of stroke, 2021 - journals.sagepub.com
Spontaneous intracerebral hemorrhage is a particularly devastating type of stroke with
greater morbidity and mortality compared with ischemic stroke and can account for half or …

Code ICH: a call to action

Q Li, A Yakhkind, AW Alexandrov, AV Alexandrov… - Stroke, 2024 - Am Heart Assoc
Intracerebral hemorrhage is the most serious type of stroke, leading to high rates of severe
disability and mortality. Hematoma expansion is an independent predictor of poor functional …

Neurosurgical intervention for supratentorial intracerebral hemorrhage

L Sondag, FHBM Schreuder, HD Boogaarts… - Annals of …, 2020 - Wiley Online Library
Objective The effect of surgical treatment for supratentorial spontaneous intracerebral
hemorrhage (ICH) and whether it is modified by key baseline characteristics and timing …

[HTML][HTML] Computed tomography in acute intracerebral hemorrhage: neuroimaging predictors of hematoma expansion and outcome

A Hillal, T Ullberg, B Ramgren, J Wassélius - Insights into imaging, 2022 - Springer
Intracerebral hemorrhage (ICH) accounts for 10–20% of all strokes worldwide and is
associated with serious outcomes, including a 30-day mortality rate of up to 40 …

[HTML][HTML] Programmed cell deaths and potential crosstalk with blood–brain barrier dysfunction after hemorrhagic stroke

Y Fang, S Gao, X Wang, Y Cao, J Lu, S Chen… - Frontiers in cellular …, 2020 - frontiersin.org
Hemorrhagic stroke is a life-threatening neurological disease characterized by high mortality
and morbidity. Various pathophysiological responses are initiated after blood enters the …

Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome

RC Nogueira, M Aries, JS Minhas… - Journal of Cerebral …, 2022 - journals.sagepub.com
Acute stroke is associated with high morbidity and mortality. In the last decades, new
therapies have been investigated with the aim of improving clinical outcomes in the acute …

[HTML][HTML] Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?

MAM Freire, GS Rocha, LO Bittencourt, D Falcao… - Biology, 2023 - mdpi.com
Simple Summary Traumatic brain injury (TBI) is a catastrophic event to the health and life of
its sufferers, and it also affects their relatives. In addition to the underlying complications of …