[HTML][HTML] COVID-19 mRNA vaccines: Platforms and current developments

GT Szabó, AJ Mahiny, I Vlatkovic - Molecular Therapy, 2022 - cell.com
Since the first successful application of messenger ribonucleic acid (mRNA) as a vaccine
agent in a preclinical study nearly 30 years ago, numerous advances have been made in …

Antibody tests for identification of current and past infection with SARS‐CoV‐2

T Fox, J Geppert, J Dinnes, K Scandrett… - Cochrane database …, 2022 - cochranelibrary.com
Background The diagnostic challenges associated with the COVID‐19 pandemic resulted in
rapid development of diagnostic test methods for detecting SARS‐CoV‐2 infection. Serology …

[HTML][HTML] COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning

E Ong, MU Wong, A Huffman, Y He - Frontiers in immunology, 2020 - frontiersin.org
To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective
and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 …

Lipid nanoparticle technology for therapeutic gene regulation in the liver

D Witzigmann, JA Kulkarni, J Leung, S Chen… - Advanced drug delivery …, 2020 - Elsevier
Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of
people around the globe and are a major public health burden. Most contemporary …

[HTML][HTML] Controlling timing and location in vaccines

DJ Irvine, A Aung, M Silva - Advanced Drug Delivery Reviews, 2020 - Elsevier
Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …

[HTML][HTML] The COVID-19 vaccines: recent development, challenges and prospects

Y Yan, Y Pang, Z Lyu, R Wang, X Wu, C You, H Zhao… - Vaccines, 2021 - mdpi.com
The highly infectious coronavirus disease 2019 (COVID-19) associated with the pathogenic
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to become a …

Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection

CJ Batty, MT Heise, EM Bachelder… - Advanced drug delivery …, 2021 - Elsevier
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has led to an unprecedented effort toward the development of an effective …

[HTML][HTML] Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines

AK Blakney, PF McKay, K Hu, K Samnuan… - Journal of controlled …, 2021 - Elsevier
Self-amplifying RNA (saRNA) is a next-generation vaccine platform, but like all nucleic
acids, requires a delivery vehicle to promote cellular uptake and protect the saRNA from …

[HTML][HTML] Outbreak of COVID-19: An emerging global pandemic threat

M Peng - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Since the first outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection in Wuhan, Hubei, China in December 2019, it is now recognized as a pandemic by …

COVID-19 vaccines:“Warp Speed” needs mind melds, not warped minds

JP Moore, PJ Klasse - Journal of virology, 2020 - Am Soc Microbiol
In this review, we address issues that relate to the rapid “Warp Speed” development of
vaccines to counter the COVID-19 pandemic. We review the antibody response that is …