Has ferrocene really delivered its role in accentuating the bioactivity of organic scaffolds?

B Sharma, V Kumar - Journal of medicinal chemistry, 2021 - ACS Publications
Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

Metal complexes for therapeutic applications

J Karges, RW Stokes, SM Cohen - Trends in chemistry, 2021 - cell.com
Metal complexes have been widely used for applications in the chemical and physical
sciences due to their unique electronic and stereochemical properties. For decades the use …

Organometallic anticancer compounds

G Gasser, I Ott, N Metzler-Nolte - Journal of medicinal chemistry, 2011 - ACS Publications
The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …

Challenges and opportunities in the development of organometallic anticancer drugs

CG Hartinger, N Metzler-Nolte, PJ Dyson - Organometallics, 2012 - ACS Publications
This review provides an introduction into the fascinating area of organometallic anticancer
compounds. Although the subject dates back many years, it has witnessed considerable …

The potential of organometallic complexes in medicinal chemistry

G Gasser, N Metzler-Nolte - Current opinion in chemical biology, 2012 - Elsevier
Organometallic complexes have unique physico-chemical properties, which have been
widely used in homogenous catalysis, for example, for the synthesis of lead compounds and …

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs

SH van Rijt, PJ Sadler - Drug discovery today, 2009 - Elsevier
This review illustrates notable recent progress in the field of medicinal bioinorganic
chemistry as many new approaches to the design of innovative metal-based anticancer …

Nanocarriers for the treatment of glioblastoma multiforme: current state-of-the-art

R Karim, C Palazzo, B Evrard, G Piel - Journal of controlled release, 2016 - Elsevier
Glioblastoma multiforme, a grade IV glioma, is the most frequently occurring and invasive
primary tumor of the central nervous system, which causes about 4% of cancer-associated …

Underestimated potential of organometallic rhenium complexes as anticancer agents

A Leonidova, G Gasser - ACS chemical biology, 2014 - ACS Publications
In the recent years, organometallic compounds have become recognized as promising anti-
cancer drug candidates. While radioactive 186/188Re compounds are already used in …

A new age for iron: antitumoral ferrocenes

SS Braga, AMS Silva - Organometallics, 2013 - ACS Publications
From the core of the earth to the core of the archetypal organometallic compound ferrocene,
iron and its compounds contribute to create many aspects of our reality: the earth's …

[HTML][HTML] Ferrocene-based compounds with antimalaria/anticancer activity

S Peter, BA Aderibigbe - Molecules, 2019 - mdpi.com
Malaria and cancer are chronic diseases. The challenge with drugs available for the
treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent …