Oxidative stress and neuroinflammation potentiate each other to promote progression of dopamine neurodegeneration

J He, G Zhu, G Wang, F Zhang - Oxidative medicine and …, 2020 - Wiley Online Library
Parkinson's disease (PD) is a chronic and complex disease of the central nervous system
(CNS). Progressive loss of dopamine (DA) neurons in midbrain substantia nigra is …

Heterocyclic amines in meat and meat products: Occurrence, formation, mitigation, health risks and intervention

Y Geng, Y Xie, W Li, J Ji, F Chen, X Liao… - Food Reviews …, 2024 - Taylor & Francis
Chemical safety of meat and meat products has gained great attention due to increasing
contamination incidents. Contaminations produced during meat processing pose a threat to …

Heterocyclic aromatic amines induce Neuro-2a cells cytotoxicity through oxidative stress-mediated mitochondria-dependent apoptotic signals

Y Feng, S Chen, Y Zhao, D Wu, G Li - Food and Chemical Toxicology, 2022 - Elsevier
Heterocyclic aromatic amines (HAAs) are a class of hazardous compounds produced in food
thermal processing. These compounds raise concerns because they have mutagenic and …

Neurotoxicity and underlying mechanisms of endogenous neurotoxins

Y Cao, B Li, N Ismail, K Smith, T Li, R Dai… - International journal of …, 2021 - mdpi.com
Endogenous and exogenous neurotoxins are important factors leading to
neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1, 2, 3, 6 …

Potential role of heterocyclic aromatic amines in neurodegeneration

T Syeda, JR Cannon - Chemical research in toxicology, 2022 - ACS Publications
Heterocyclic aromatic amines (HAAs) are mainly formed in the pyrolysis process during high-
temperature cooking of meat. Meat consumption is very typical of the western diet, and the …

Nuclear DNA and Mitochondrial Damage of the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Human Neuroblastoma Cells

M Bellamri, K Brandt, K Cammerrer… - Chemical research in …, 2023 - ACS Publications
Animal fat and iron-rich diets are risk factors for Parkinson's disease (PD). The heterocyclic
aromatic amines (HAAs) harman and norharman are neurotoxicants formed in many foods …

Neuromelanin: Its role in the pathogenesis of idiopathic Parkinson's disease and potential as a therapeutic target

R Mitra, L Premraj, TK Khoo - Parkinsonism & Related Disorders, 2023 - Elsevier
Parkinson's disease is an increasingly prevalent condition that involves the marked loss of
dopaminergic neurons in the substantia nigra pars compacta. These neurons pigmented …

[HTML][HTML] Study of enzymatic activity in human neuroblastoma cells SH-SY5Y exposed to zearalenone's derivates and beauvericin

F Agahi, A Juan-García, G Font, C Juan - Food and Chemical Toxicology, 2021 - Elsevier
Abstract Beauvericin (BEA), α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL), are produced
by several Fusarium species that contaminate cereal grains. These mycotoxins can cause …

Neuromelanin formation exacerbates HAA-induced mitochondrial toxicity and mitophagy impairments

V Lawana, SY Um, RM Foguth, JR Cannon - Neurotoxicology, 2020 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is a major public
health concern due in part to prevalence, debilitating symptoms, and links to environmental …

Butyrylcholinesterase-inhibiting natural coumarin molecules as potential leads

IE Orhan, F Tosun, FSS Deniz, G Eren, F Mıhoğlugil… - Phytochemistry …, 2021 - Elsevier
Seventeen natural coumarin derivatives; badrakemin (1), 14′-acetoxybadrakemin (2),
badrakemone (3), 14′-acetoxybadrakemone (4), colladonin (5), colladonin acetate (6) …