[HTML][HTML] Cancer vaccines, adjuvants, and delivery systems

SJ Paston, VA Brentville, P Symonds… - Frontiers in …, 2021 - frontiersin.org
Vaccination was first pioneered in the 18th century by Edward Jenner and eventually led to
the development of the smallpox vaccine and subsequently the eradication of smallpox. The …

Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives

O Ciesielski, M Biesiekierska, B Panthu… - Cellular and Molecular …, 2022 - Springer
Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell
through altering the structure and functions of proteins. The action of the most prevalent …

Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

X Wu, M Xu, M Geng, S Chen, PJ Little, S Xu… - Signal transduction and …, 2023 - nature.com
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Proteomics of post-translational modifications in colorectal cancer: Discovery of new biomarkers

G Zhu, L Jin, W Sun, S Wang, N Liu - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Colorectal cancer (CRC) is one of the costliest health problems and ranks second in cancer-
related mortality in developed countries. With the aid of proteomics, many protein …

Autoimmunity roots of the thrombotic events after COVID-19 vaccination

F Elrashdy, MM Tambuwala, SS Hassan, P Adadi… - Autoimmunity …, 2021 - Elsevier
Although vaccination represents the most promising way to stop or contain the coronavirus
disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines …

Post-translational modifications in tumor-associated antigens as a platform for novel immuno-oncology therapies

AK Srivastava, G Guadagnin, P Cappello, F Novelli - Cancers, 2022 - mdpi.com
Simple Summary Tumor-associated antigens (TAAs) are antigens present in tumor cells, but
are also expressed in normal cells. However, TAAs are aberrantly expressed by tumor cells …

PAD4 and its inhibitors in cancer progression and prognosis

D Zhu, Y Lu, Y Wang, Y Wang - Pharmaceutics, 2022 - mdpi.com
The systemic spread of malignancies and the risk of cancer-associated thrombosis are
major clinical challenges in cancer therapy worldwide. As an important post-translational …

Impact of posttranslational modification in pathogenesis of rheumatoid arthritis: focusing on citrullination, carbamylation, and acetylation

EJ Kwon, JH Ju - International journal of molecular sciences, 2021 - mdpi.com
Rheumatoid arthritis (RA) is caused by prolonged periodic interactions between genetic,
environmental, and immunologic factors. Posttranslational modifications (PTMs) such as …

Molecular drivers of developmental arrest in the human preimplantation embryo: a systematic review and critical analysis leading to mapping future research

K Sfakianoudis, E Maziotis, E Karantzali… - International journal of …, 2021 - mdpi.com
Developmental arrest of the preimplantation embryo is a multifactorial condition,
characterized by lack of cellular division for at least 24 hours, hindering the in vitro …

Peptidyl arginine deiminase 2 (PADI2)-mediated arginine citrullination modulates transcription in cancer

M Beato, P Sharma - International Journal of Molecular Sciences, 2020 - mdpi.com
Protein arginine deimination leading to the non-coded amino acid citrulline remains a key
question in the field of post-translational modifications ever since its discovery by Rogers …