Abstract 'Orang-utan'is derived from a Malay term meaning 'man of the forest'and aptly
describes the southeast Asian great apes native to Sumatra and Borneo. The orang-utan …

Presented here is a genome sequence of an individual human. It was produced from∼ 32
million random DNA fragments, sequenced by Sanger dideoxy technology and assembled …

Although present in both humans and chimpanzees, recombination hotspots, at which
meiotic crossover events cluster, differ markedly in their genomic location between the …

Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Thousands of genes encoding long noncoding RNAs (lncRNAs) have been identified in all
vertebrate genomes thus far examined. The list of lncRNAs partaking in arguably important …

Abstract The Human Gene Mutation Database (HGMD®) is a comprehensive core collection
of germline mutations in nuclear genes that underlie or are associated with human inherited …

All attempts at treating strokes by pharmacologically reducing the human brain's
vulnerability to ischaemia have failed, leaving stroke as a leading cause of death, disability …

Background The process of generating raw genome sequence data continues to become
cheaper, faster, and more accurate. However, assembly of such data into high-quality …

Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Although there have been major advances in elucidating the functional biology of the human
brain, relatively little is known of its cellular and molecular organization. Here we report a …