Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …

MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children
following COVID-19 infection. This review summarizes the literature on diagnosis …

Background Organ congestion is a mediator of adverse outcomes in critically ill patients.
Point-Of-Care ultrasound (POCUS) is widely available and could enable clinicians to detect …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

This article presents a personal viewpoint of the shortcoming of conventional hemodynamic
resuscitation procedures in achieving organ perfusion and tissue oxygenation following …

The lung is highly vulnerable during sepsis, yet its functional deterioration accompanied by
disturbances in the pulmonary microcirculation is poorly understood. This study aimed to …

Endothelial cells line the inner portion of the heart, blood vessels, and lymphatic vessels; a
basal membrane of extracellular matrix lines the extraluminal side of endothelial cells. The …

The endothelium provides an essential and selective membrane barrier that regulates the
movement of water, solutes, gases, macromolecules and the cellular elements of the blood …

Methods This was a substudy of a multicenter trial in which nonbleeding critically ill patients
with an increased International Normalized Ratio (1.5 to 3.0) were randomized to omitting or …

Sepsis is a multifactorial syndrome primarily determined by the host response to an invading
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …