Computational study of the pH-dependent competition between carbonate and thymine addition to the guanine radical
SP Hebert, HB Schlegel - Chemical Research in Toxicology, 2018 - ACS Publications
When oligonucleotides are oxidized by carbonate radical, thymine and carbonate can add to
guanine radical, yielding either a guanine-thymine cross-link product (G∧ T) or 8-oxo-7, 8 …
guanine radical, yielding either a guanine-thymine cross-link product (G∧ T) or 8-oxo-7, 8 …
Mutagenicity associated with O6-methylguanine-DNA damage and mechanism of nucleotide flipping by AGT during repair
Methylated guanine damage at O6 position (ie O6MG) is dangerous due to its mutagenic
and carcinogenic character that often gives rise to G: C–A: T mutation. However, the reason …
and carcinogenic character that often gives rise to G: C–A: T mutation. However, the reason …
Reactivities of hydroxyl and perhydroxyl radicals toward cytosine and thymine: a comparative study
As the hydroxyl (OH) and perhydroxyl (OOH) radicals are known to play important roles in
biological systems, their reactions with cytosine and thymine were studied. Addition …
biological systems, their reactions with cytosine and thymine were studied. Addition …
Urocanic acid as an efficient hydroxyl radical scavenger: a quantum theoretical study
S Tiwari, P Chand Mishra - Journal of molecular modeling, 2011 - Springer
The photoisomerization of urocanic acid (UCA)—which is present in human skin epidermis,
where it acts as a sunscreen—from its trans isomer to its cis isomer upon exposure to UV-B …
where it acts as a sunscreen—from its trans isomer to its cis isomer upon exposure to UV-B …
DFT mechanistic study on the formation of 8-oxoguanine and spiroiminodihydantoin mediated by iron Fenton reactions
HY Chen, YF Lin - Dalton Transactions, 2021 - pubs.rsc.org
Fenton reactions unavoidably take place in the human body and have been demonstrated to
cause oxidative DNA damage. However, the molecular-level understanding of DNA damage …
cause oxidative DNA damage. However, the molecular-level understanding of DNA damage …
Ab initio study of guanine damage by hydroxyl radical
GM Chaban, D Wang, WM Huo - The Journal of Physical …, 2015 - ACS Publications
Multiconfigurational ab initio methods are used in this study to examine two initial reactions
that take place during the OH radical attack of the DNA base guanine: a ring opening …
that take place during the OH radical attack of the DNA base guanine: a ring opening …
Is FapyG mutagenic?: Evidence from the DFT study
diamino‐4‐oxo‐5‐formamidopyrimidine (FapyG) is an oxidatively damaged product of
guanine (G), which is mainly formed through metabolic processes that produce OH radicals …
guanine (G), which is mainly formed through metabolic processes that produce OH radicals …
DFT study on addition reaction mechanism of guanine‐cytosine base pair with OH radical
M Li, L Diao, X Liao, L Kou, W Lu - Journal of Physical Organic …, 2015 - Wiley Online Library
The addition reaction mechanism of OH radical with guanine‐cytosine (GC) base pair has
been explored at the B3LYP/DZP++ level of density functional theory (DFT). Structures …
been explored at the B3LYP/DZP++ level of density functional theory (DFT). Structures …
[HTML][HTML] Recurrence of paraproteinemic keratopathy after penetrating keratoplasty and its assessment with confocal microscopy
J Wasielica-Poslednik, A Gericke, A Desuki… - American Journal of …, 2018 - Elsevier
Purpose To report on a case of recurrence of paraproteinemic keratopathy (PPK) associated
with monoclonal gammopathy after bilateral penetrating keratoplasty. Observations …
with monoclonal gammopathy after bilateral penetrating keratoplasty. Observations …
Carbonate radical anion as an efficient reactive oxygen species: Its reaction with guanyl radical and formation of 8-oxoguanine
Mechanisms of reactions of four different tautomers (G (-H1)·, G (-H2a)·, G (-H2b)· and G (-
H9)·) of guanyl radical with carbonate radical anion (CO3.−) producing the mutagenic …
H9)·) of guanyl radical with carbonate radical anion (CO3.−) producing the mutagenic …