Conformational stabilities of iminoallantoin and its base pairs in DNA: implications for mutagenicity
The types of mutations induced by oxidatively damaged products of DNA are continuously in
debate. For example, some biochemical studies have proposed that guanidinohydantoin …
debate. For example, some biochemical studies have proposed that guanidinohydantoin …
Does tautomerization of FapyG influence its mutagenicity?
Oxidative degradation of guanine to 2, 6‐diamino‐4‐oxo‐5‐formamidopyrimidine (FapyG) is
believed to be mutagenic. It has been proposed recently that the enol tautomer of FapyG is …
believed to be mutagenic. It has been proposed recently that the enol tautomer of FapyG is …
The R-and S-diastereoisomeric effects on the guanidinohydantoin-induced mutations in DNA
Direct and indirect oxidation of guanine in DNA produces guanidinohydantoin (Gh), which is
capable of inhibiting replication and inducing mutations during cellular activities. Although …
capable of inhibiting replication and inducing mutations during cellular activities. Although …
H2O3 as a Reactive Oxygen Species: Formation of 8-Oxoguanine from Its Reaction with Guanine
Reaction of guanine with H2O3 in the absence and presence of a water molecule leading to
the formation of 8-oxoguanine (8-oxoG) was investigated. Initial calculations were performed …
the formation of 8-oxoguanine (8-oxoG) was investigated. Initial calculations were performed …
Reactions of the OOH radical with guanine: mechanisms of formation of 8-oxoguanine and other products
The mutagenic product 8-oxoguanine (8-oxoGua) is formed due to intermediacy of peroxyl
(OOR) radicals in lipid peroxidation and protein oxidation-induced DNA damage. The …
(OOR) radicals in lipid peroxidation and protein oxidation-induced DNA damage. The …
Ground-and excited-state proton transfer and rotamerism in 2-(2-Hydroxyphenyl)-5-phenyl-1, 3, 4-oxadiazole and Its O/“NH or S”-substituted derivatives
Z Yang, S Yang, J Zhang - The Journal of Physical Chemistry A, 2007 - ACS Publications
The intramolecular proton-transfer process, rotational process, and optical properties of 2-(2-
hydroxyphenyl)-5-phenyl-1, 3, 4-oxadiazole (HOXD) and its O/“NH”-and O/“S”-substituted …
hydroxyphenyl)-5-phenyl-1, 3, 4-oxadiazole (HOXD) and its O/“NH”-and O/“S”-substituted …
Computational study of the formation of C8, C5, and C4 guanine: lysine adducts via oxidation of guanine by sulfate radical anion
Oxidative damage to DNA can lead to DNA–protein cross-links which can interfere with DNA
transcription, replication, and repair. In experimental studies modeling oxidative damage to …
transcription, replication, and repair. In experimental studies modeling oxidative damage to …
Quantum theoretical study of cleavage of the glycosidic bond of 2′-deoxyadenosine: base excision-repair mechanism of DNA by MutY
S Tiwari, N Agnihotri, PC Mishra - The Journal of Physical …, 2011 - ACS Publications
The enzyme adenine DNA glycosylase, also called MutY, is known to catalyze base excision
repair by removal of adenine from the abnormal 2′-deoxyadenosine: 8-oxo-2 …
repair by removal of adenine from the abnormal 2′-deoxyadenosine: 8-oxo-2 …
The DNA repair protein NBS1 influences the base excision repair pathway
D Sagan, R Müller, C Kröger, A Hematulin… - …, 2009 - academic.oup.com
NBS1 fulfills important functions for the maintenance of genomic stability and cellular
survival. Mutations in the NBS1 (Nijmegen Breakage Syndrome 1) gene are responsible for …
survival. Mutations in the NBS1 (Nijmegen Breakage Syndrome 1) gene are responsible for …
A theoretical study of some new analogues of the anti-cancer drug camptothecin
The enzyme topoisomerase I (topo I), which is essential for cell replication, transiently
causes a DNA single strand break and makes a complex with it. The anti-cancer agent …
causes a DNA single strand break and makes a complex with it. The anti-cancer agent …