In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

Aiming at a formulation of a cytokine model of cognitive function under immunologically
unchallenged physiological conditions, this article reviews the cytokine biology in the central …

Neuroplasticity is not only shaped by learning and memory but is also a mediator of
responses to neuron attrition and injury (compensatory plasticity). As an ongoing process it …

Substantial basic science and clinical evidence suggests that excess tumor necrosis factor-
alpha (TNF-alpha) is centrally involved in the pathogenesis of Alzheimer's disease. In …

Objective The purpose of this study is to characterize functional connectivity changes in mild
cognitive impaired Alzheimer's disease (MCI-AD) under resting and cognitive task …

Tumour necrosis factor (TNF), a key regulator of varied physiological mechanisms in
multiple organ systems, is an immune signalling molecule produced by glia, neurons …

The past decade has witnessed exciting breakthroughs that have contributed to the richness
and complexity of a burgeoning modern RNA world, and one particular breakthrough—the …

Evidence is accumulating for a role for amyloid peptides in impaired synaptic plasticity and
cognition, while the underlying mechanisms remain unclear. We here analyzed the effects of …

Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease. Recent studies
employing microRNA-seq and genome-wide sequencing have identified some non-coding …

Neural plasticity—the ability to alter a neuronal response to environmental stimuli—is an
important factor in learning and memory. Short‐term synaptic plasticity and long‐term …