Evidence-based medical therapy in patients with heart failure with reduced ejection fraction and chronic kidney disease

IE Beldhuis, CSP Lam, JM Testani, AA Voors… - Circulation, 2022 - Am Heart Assoc
Chronic kidney disease (CKD) as identified by a reduced estimated glomerular filtration rate
(eGFR) is a common comorbidity in patients with heart failure with reduced ejection fraction …

Sodium–glucose co‐transporter 2 inhibitors as an early, first‐line therapy in patients with heart failure and reduced ejection fraction

D Tomasoni, GC Fonarow, M Adamo… - European journal of …, 2022 - Wiley Online Library
Sodium–glucose co‐transporter 2 (SGLT2) inhibitors have recently been recommended as a
foundational therapy for patients with heart failure (HF) and reduced ejection fraction …

Cardiovascular events with finerenone in kidney disease and type 2 diabetes

B Pitt, G Filippatos, R Agarwal, SD Anker… - … England Journal of …, 2021 - Mass Medical Soc
Background Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist, has
favorable effects on cardiorenal outcomes in patients with predominantly stage 3 or 4 …

Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial

J Butler, SD Anker, LH Lund, AJS Coats… - European heart …, 2022 - academic.oup.com
Aims To investigate the impact of patiromer on the serum potassium level and its ability to
enable specified target doses of renin–angiotensin–aldosterone system inhibitor (RAASi) …

Renal effects of guideline‐directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology

W Mullens, P Martens, JM Testani… - European journal of …, 2022 - Wiley Online Library
Novel pharmacologic treatment options reduce mortality and morbidity in a cost‐effective
manner in patients with heart failure (HF). Undisputedly, the effective implementation of …

Heart failure drug titration, discontinuation, mortality and heart failure hospitalization risk: a multinational observational study (US, UK and Sweden)

G Savarese, J Bodegard, A Norhammar… - European journal of …, 2021 - Wiley Online Library
Aims Use and dosing of guideline‐directed medical therapy (GDMT) in patients with heart
failure (HF) have been shown to be suboptimal. Among new users of GDMT in HF, we …

Pre‐discharge and early post‐discharge management of patients hospitalized for acute heart failure: A scientific statement by the Heart Failure Association of the ESC

M Metra, M Adamo, D Tomasoni… - European Journal of …, 2023 - Wiley Online Library
Acute heart failure is a major cause of urgent hospitalizations. These are followed by marked
increases in death and rehospitalization rates, which then decline exponentially though they …

Use of guideline‐recommended medical therapy in patients with heart failure and chronic kidney disease: from physician's prescriptions to patient's dispensations …

RJ Janse, EL Fu, U Dahlström, L Benson… - European Journal of …, 2022 - Wiley Online Library
Aim Half of heart failure (HF) patients have chronic kidney disease (CKD) complicating their
pharmacological management. We evaluated physicians' and patients' patterns of use of …

Finerenone in patients with chronic kidney disease and type 2 diabetes with and without heart failure: a prespecified subgroup analysis of the FIDELIO‐DKD trial

G Filippatos, B Pitt, R Agarwal… - European Journal of …, 2022 - Wiley Online Library
Aims This prespecified analysis of the FIDELIO‐DKD trial compared the effects of
finerenone, a selective non‐steroidal mineralocorticoid receptor antagonist, on cardiorenal …

Cardiac and kidney benefits of empagliflozin in heart failure across the spectrum of kidney function: Insights from the EMPEROR‐Preserved trial

A Sharma, JP Ferreira, F Zannad… - European journal of …, 2023 - Wiley Online Library
Abstract Aim In the EMPEROR‐Preserved trial, empagliflozin improved clinical outcomes of
patients with heart failure (HF) with preserved ejection fraction. In this pre‐specified analysis …