Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Computational models of atrial fibrillation: Achievements, challenges, and perspectives for improving clinical care

J Heijman, H Sutanto, HJGM Crijns… - Cardiovascular …, 2021 - academic.oup.com
Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …

Interleukin-6-Mediated-Ca2+ Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats

J Liao, S Zhang, S Yang, Y Lu, K Lu, Y Wu… - Frontiers in …, 2021 - frontiersin.org
Pre-existing Ca2+ handling abnormalities constitute the arrhythmogenic substrate in
patients developing postoperative atrial fibrillation (POAF), a common complication after …

Mechanisms and drug development in atrial fibrillation

D Calvo, D Filgueiras-Rama, J Jalife - Pharmacological Reviews, 2018 - ASPET
Atrial fibrillation is a highly prevalent cardiac arrhythmia and the most important cause of
embolic stroke. Although genetic studies have identified an increasing assembly of AF …

[HTML][HTML] Cardiac dynamics: alternans and arrhythmogenesis

G Tse, ST Wong, V Tse, YT Lee, HY Lin, JM Yeo - Journal of Arrhythmia, 2016 - Elsevier
Pre-existing heterogeneities present in cardiac tissue are essential for maintaining the
normal electrical and mechanical functions of the heart. Exacerbation of such …

Low‐level tragus stimulation modulates atrial alternans and fibrillation burden in patients with paroxysmal atrial fibrillation

K Kulkarni, JP Singh, KA Parks… - Journal of the …, 2021 - Am Heart Assoc
Background Low‐level tragus stimulation (LLTS) has been shown to significantly reduce
atrial fibrillation (AF) burden in patients with paroxysmal AF. P‐wave alternans (PWA) is …

Computational modeling of electrophysiology and pharmacotherapy of atrial fibrillation: recent advances and future challenges

M Vagos, IGM van Herck, J Sundnes… - Frontiers in …, 2018 - frontiersin.org
The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …

[HTML][HTML] Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation–remodeled hearts

T Liu, F Xiong, XY Qi, J Xiao, L Villeneuve, I Abu-Taha… - JCI insight, 2020 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ handling, promoting ectopic
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …

Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation

J Heijman, P Erfanian Abdoust, N Voigt… - The Journal of …, 2016 - Wiley Online Library
The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …

How computer simulations of the human heart can improve anti‐arrhythmia therapy

NA Trayanova, KC Chang - The Journal of physiology, 2016 - Wiley Online Library
Over the last decade, the state‐of‐the‐art in cardiac computational modelling has
progressed rapidly. The electrophysiological function of the heart can now be simulated with …