Guidelines for in vivo mouse models of myocardial infarction

ML Lindsey, KR Brunt, JA Kirk… - American Journal …, 2021 - journals.physiology.org
Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Discovery of new therapeutic redox targets for cardioprotection against ischemia/reperfusion injury and heart failure

A Daiber, I Andreadou, M Oelze, SM Davidson… - Free Radical Biology …, 2021 - Elsevier
Global epidemiological studies reported a shift from maternal/infectious communicable
diseases to chronic non-communicable diseases and a major part is attributable to …

Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction

L Feng, B Li, Y Xi, M Cai, Z Tian - American Journal of …, 2022 - journals.physiology.org
Myocardial infarction (MI)-induced heart failure (HF) is commonly accompanied with
profound effects on skeletal muscle. With the process of MI-induced HF, perturbations in …

[HTML][HTML] Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities

J Lv, Y Li, S Shi, X Xu, H Wu, B Zhang… - Biomedicine & …, 2022 - Elsevier
Patients with heart failure (HF) usually present with skeletal muscle diseases of varying
severity, ranging from early fatigue on exercise to sarcopenia, sarcopenic obesity or …

Irisin and ALCAT1 mediated aerobic exercise-alleviated oxidative stress and apoptosis in skeletal muscle of mice with myocardial infarction

W Ren, Z Xu, S Pan, Y Ma, H Li, F Wu, W Bo… - Free Radical Biology …, 2022 - Elsevier
Skeletal muscle in patients with heart failure (HF) exhibits altered structure, function and
metabolism. Myocardial infarction (MI) is the most common cause of HF. Oxidative stress …

Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction

D Jia, Z Tian, R Wang - Ageing Research Reviews, 2023 - Elsevier
The benefits of regular physical activity are related to delaying and reversing the onset of
ageing and age-related disorders, including cardiomyopathy, neurodegenerative diseases …

Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure

S Takada, S Maekawa, T Furihata… - Proceedings of the …, 2022 - National Acad Sciences
Heart failure (HF) is a leading cause of death and repeated hospitalizations and often
involves cardiac mitochondrial dysfunction. However, the underlying mechanisms largely …

Uric acid associated with acute heart failure presentation in Acute Coronary Syndrome patients

P Rebora, M Centola, N Morici, A Sacco… - European Journal of …, 2022 - Elsevier
We focused on the role of Uric Acid (UA) as a possible determinant of Heart Failure (HF)
related issues in Acute Coronary Syndromes (ACS) patients. Main outcomes were acute HF …

[HTML][HTML] Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats

T Koizumi, M Watanabe, T Yokota, M Tsuda… - Frontiers in …, 2023 - frontiersin.org
Introduction Recent studies have demonstrated that sodium-glucose co-transporter-2
inhibitors (SGLT2-i) reduce the risk of atrial fibrillation (AF) in patients with diabetes mellitus …

Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice

Y Tanaka, T Nagoshi, A Yoshii, Y Oi… - Free Radical Biology …, 2021 - Elsevier
Accumulating evidence suggests that high serum uric acid (UA) is associated with left
ventricular (LV) dysfunction. Although xanthine oxidase (XO) activation is a critical regulatory …