Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Alterations of chromatin structure have been shown to be crucial for response to cell
signaling and for programmed gene expression in development. Posttranslational histone …

Regulation of gene transcription is vitally important for the maintenance of normal cellular
homeostasis. Failure to correctly regulate gene expression, or to deal with problems that …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within
proteins are modified on multiple amino acid sidechains by diverse enzymes to create a …

Eukaryotic transcription occurs on chromatin, where RNA polymerase II encounters
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …

Traditionally the stratification of many cancers involves combining tumour and
clinicopathological features (eg, patient age; tumour size, grade, receptor status and …

Mammalian oocyte maturation and embryo development are unique biological processes
regulated by various modifications. Since de novo mRNA transcription is absent during …

DNA in human cells is constantly assaulted by endogenous and exogenous DNA damaging
agents. It is vital for the cell to respond rapidly and precisely to DNA damage to maintain …

Protein lysine methyltransferases (PKMTs) transfer up to three methyl groups to the side
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …