HEXIM1 plays a critical role in the inhibition of the androgen receptor by anti-androgens
IJ Yeh, K Song, BM Wittmann, X Bai… - Biochemical …, 2014 - portlandpress.com
We show that HEXIM1 (hexamethylene bis-acetamide inducible 1) functions as an AR
(androgen receptor) co-repressor as it physically interacts with the AR and is required for the …
(androgen receptor) co-repressor as it physically interacts with the AR and is required for the …
Histone modifications, stem cells and prostate cancer
Prostate cancer (PCa) is a very common neoplasm, which is generally treated by chemo-,
radio-, and/or hormonal-therapy. After a variable time, PCa becomes resistant to …
radio-, and/or hormonal-therapy. After a variable time, PCa becomes resistant to …
Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo
Background Differential accessibility of DNA to nuclear proteins underlies the regulation of
numerous cellular processes. Although DNA accessibility is primarily determined by the …
numerous cellular processes. Although DNA accessibility is primarily determined by the …
[HTML][HTML] Chromatin modifiers in transcriptional regulation: new findings and prospects
MM Yu - Acta Naturae (англоязычная версия), 2021 - cyberleninka.ru
Histone-modifying and remodeling complexes are considered the main coregulators that
affect transcription by changing the chromatin structure. Coordinated action by these …
affect transcription by changing the chromatin structure. Coordinated action by these …
Characterization of paucibacillary ileal lesions in sheep with subclinical active infection by Mycobacterium avium subsp. paratuberculosis
S Pisanu, T Cubeddu, C Cacciotto, Y Pilicchi… - Veterinary …, 2018 - Springer
Paratuberculosis (PTB) or Johne's disease is a contagious enteritis of ruminants caused by
Mycobacterium avium subsp. paratuberculosis (MAP). Ovine PTB is less understood than …
Mycobacterium avium subsp. paratuberculosis (MAP). Ovine PTB is less understood than …
[HTML][HTML] INAUGURAL ARTICLE by a Recently Elected Academy Member: Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome
S Rahman, NA Hoffmann, EJ Worden… - Proceedings of the …, 2022 - ncbi.nlm.nih.gov
Results Structure Determination of Multiple MLL1-WRAD States. We determined the
structure of the human MLL1-WRAD complex (17) bound to a ubiquitinated nucleosome …
structure of the human MLL1-WRAD complex (17) bound to a ubiquitinated nucleosome …
The dynamics and functional mechanisms of H2B mono-ubiquitination
Y Li, T Ma, J Jiang, M Hahn, Y Yin - Crop Health, 2024 - Springer
H2B mono-ubiquitination (ub1) is an important histone modification attaching a ubiquitin
moiety to the small histone H2B and changing the biochemical features of the chromatin …
moiety to the small histone H2B and changing the biochemical features of the chromatin …
The evolutionarily conserved factor Sus1/ENY2 plays a role in telomere length maintenance
A Galán, E García-Oliver, C Nuño-Cabanes… - Current genetics, 2018 - Springer
Sus1 is a conserved protein involved in histone H2B de-ubiquitination and mRNA export
from the nucleus in eukaryotes. Previous studies implicated Sus1 partners in genome …
from the nucleus in eukaryotes. Previous studies implicated Sus1 partners in genome …
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat
A Leung, I Cajigas, P Jia, E Ezhkova… - Molecular biology of …, 2011 - Am Soc Cell Biol
In Saccharomyces cerevisiae, ubiquitylation of histone H2B signals methylation of histone
H3 at lysine residues 4 (K4) and 79. These modifications occur at active genes but are …
H3 at lysine residues 4 (K4) and 79. These modifications occur at active genes but are …
A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression
S Shah, MA Henriksen - Journal of Biological Chemistry, 2011 - ASBMB
JAK-STAT-activated gene expression is both rapid and transient and requires dynamic post-
translational modification of the chromatin template. Previously, we showed that following …
translational modification of the chromatin template. Previously, we showed that following …