Background: Chronic kidney disease (CKD) poses a global health challenge, and it needs
alternative therapeutic approaches for patients with end-stage renal disease (ESRD) …

Diabetes can be treated with β cell replacement therapy, where a patient is transplanted with
cadaveric human islets to restore glycemic control. Despite this being an effective treatment …

Organic anion transporters 1 and 3 (OAT1 and OAT3) play a crucial role in kidney function
by regulating the secretion of multiple renally cleared small molecules and toxic metabolic …

Abstract Development of a suitable vascular network for an efficient mass exchange is
crucial to generate three-dimensional (3D) viable and functional thick construct in tissue …

Chronic and end stage renal disease (ESRD) have reached pandemic levels and pose a
substantial public health burden. Unfortunately, available therapies lack efficacy in …

The extracellular matrix (ECM) is an essential network entity surrounding and supporting
cells to guarantee their physiological function and homeostasis. It is important to choose the …

Kidney regeneration is a complex process that can only be studied in vitro at a limited
capacity due to the inherent structural and functional complexity of its tissues. Thus, a …

Worldwide, increasing numbers of patients are developing end-stage renal disease, and at
present, the only treatment options are dialysis or kidney transplantation. Dialysis is …

6, 689, 161 B2 2/2004 Chen et al. 6, 749, 064 B1 6/2004 Alrey 6, 753, 181 B2 6/2004 Atala
et al. 6, 960, 427 B2 11/2005 Haverich et al. 6, 962, 814 B2 11/2005 Mitchell et al. 7, 311 …

Kidney morphogenesis and patterning have been extensively studied in animal models
such as the mouse and zebrafish. These seminal studies have been key to define the …