[HTML][HTML] Advances in the Discovery of Efflux Pump Inhibitors as Novel Potentiators to Control Antimicrobial-Resistant Pathogens

S Zhang, J Wang, J Ahn - Antibiotics, 2023 - mdpi.com
The excessive use of antibiotics has led to the emergence of multidrug-resistant (MDR)
pathogens in clinical settings and food-producing animals, posing significant challenges to …

[PDF][PDF] Phytochemistry and pharmacology of Imperata cylindrica: A comprehensive review

P Nayim, AT Mbaveng, K Sudhir… - Invest Med Chem …, 2023 - researchgate.net
Background: Imperata cylindrica is a medicinal spice used in traditional medicine to cure
several ailments including cancer, wounds, hypertension, and inflammation. The current …

[PDF][PDF] Psidium guajava (Myrtaceae) re-sensitizes multidrug-resistant Pseudomonas aeruginosa over-expressing MexAB-OprM efflux pumps to commonly prescribed …

RS Tiotsop, AT Mbaveng, AJ Seukep… - Invest Med Chem …, 2023 - researchgate.net
Background: Pseudomonas aeruginosa is a critical-class priority pathogen showing high
resistance to almost all classes of conventional antibiotics. As a result, discovering new …

[HTML][HTML] Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections

K Pacyga, P Pacyga, E Topola, S Viscardi… - International Journal of …, 2024 - mdpi.com
The rising prevalence of drug-resistant bacteria underscores the need to search for
innovative and nature-based solutions. One of the approaches may be the use of plants that …

[HTML][HTML] Investigating the anti-growth, anti-resistance, and anti-virulence activities of Schoepfia schreberi JF Gmel. against the superbug Acinetobacter baumannii

AH Uc-Cachón, A Dzul-Beh, M González-Cortázar… - Heliyon, 2024 - cell.com
Schoepfia schreberi has been used in Mayan folk medicine to treat diarrhea and cough. This
study aimed to determine the anti-growth, anti-resistance, and/or anti-virulence activities of …

Bacteria-targeted magnolol-loaded multifunctional nanocomplexes for antibacterial and anti-inflammatory treatment

J Jiang, X Hou, K Xu, K Ji, Z Ji, J Xi… - Biomedical Materials, 2024 - iopscience.iop.org
28 Abstract 29 Natural plant-derived small molecules have shown great potential for their
antimicrobial and anti-30 inflammatory properties. In this study, we successfully developed a …

Secondary Metabolites: Treasure Trove for Future Medicine

R Mitra, S Ghosh, G Mukherjee… - Plant Specialized …, 2023 - Springer
Secondary metabolites are organic substances produced by various living organisms (eg,
bacteria, fungi, plants, animals) that do not have any direct influence in the normal …

[PDF][PDF] Botanicals from Aframomum letestuanum Gagnep.(Zingiberaceae) can overcome the multidrug resistance of Klebsiella species overexpressing AcrAB-TolC …

GK Fonkou, VY Matieta, SM Tiwa, R Ngakam… - investchempharma.com
Background: Bacteria belonging to the genus Klebsiella have developed resistance
mechanisms to clinically used antibiotics, leading to their loss of efficacy. In the present …

[PDF][PDF] Antibacterial potential and modes of action of methanol extracts of flowers and leaves of Vernonia glabra (Steetz) Vatke (Asteraceae) against multidrug-resistant …

R Ngakam, VY Matieta, GK Fonkou, SM Tiwa… - investchempharma.com
Background: Bacterial infections caused by multidrug-resistant (MDR) Gram-negative
bacteria remain a public health problem and have contributed to a reduction in the range of …

[PDF][PDF] Unveiling the antibacterial potential and antibiotic-resistance breaker activity of Syzygium jambos (Myrtaceae) towards critical-class priority pathogen Klebsiella …

F Guefack, P Nayim, AT Mbaveng, V Kuete - investchempharma.com
Background: Klebsiella has developed multiple-drug resistance (MDR) to a wide range of
medicines, including carbapenems and third generation cephalosporins which are often …