The cuprizone mouse model allows the investigation of the complex molecular mechanisms
behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is …

Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …

Changes in gene expression that occur across the central nervous system (CNS) during
neurological diseases do not address the heterogeneity of cell types from one CNS region to …

Introduction. Human neurodegenerative diseases increase progressively with age and
present a high social and economic burden. Growth hormone (GH) and insulin-like growth …

The inability of the mammalian central nervous system (CNS) to undergo spontaneous
regeneration has long been regarded as a central tenet of neurobiology. However, although …

To date, scientific research has often focused on one sex, with assumptions that study of the
other sex would yield similar results. However, many diseases affect males and females …

Neuroprotective, anti-inflammatory, and remyelinating properties of androgens are well-
characterized in demyelinated male mice and men suffering from multiple sclerosis …

Transsexualism describes the condition when a person's psychological gender differs from
his or her biological sex and is commonly thought to arise from a discrepant cerebral and …

Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during
development and throughout adulthood. They result from a complex and well controlled …

Motor neuron-extrinsic mechanisms have been shown to participate in the pathogenesis of
ALS-SOD1, one familial form of amyotrophic lateral sclerosis (ALS). It remains unclear …