Inotuzumab ozogamicin in B-cell precursor acute lymphoblastic leukemia: efficacy, toxicity, and practical considerations

JD Rubinstein, MM O'Brien - Frontiers in Immunology, 2023 - frontiersin.org
Inotuzumab ozogamicin (InO) is an antibody drug conjugate composed of a humanized
monoclonal antibody targeting the cell surface receptor CD22 coupled to a cytotoxic …

Hepatobiliary disease after bone marrow transplant

MGF Dezan, LN Cavalcante, HP Cotrim… - Expert Review of …, 2023 - Taylor & Francis
Introduction Bone marrow transplantation (BMT) is the standard treatment for several
hematologic pathologies. Post-BMT patients may develop hepatobiliary complications that …

Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant …

T Ruutu, C Peczynski, M Houhou, E Polge… - Bone Marrow …, 2023 - nature.com
The current incidence, diagnostic policy, management, and outcome of VOD/SOS at EBMT
centers were studied. All centers that had performed allogeneic HSCTs in adult patients …

A pilot trial of prophylactic defibrotide to prevent serious thrombotic microangiopathy in high‐risk pediatric patients

CS Higham, KA Shimano, A Melton… - Pediatric Blood & …, 2022 - Wiley Online Library
Background Transplant‐associated thrombotic microangiopathy (TA‐TMA) is an endothelial
injury complication of hematopoietic stem cell transplant (HSCT) leading to end‐organ …

Incidence and risk factors for acute kidney injury after allogeneic stem cell transplantation: a prospective study

A Andronesi, B Sorohan, A Burcea, L Lipan… - Biomedicines, 2022 - mdpi.com
(1) Background: Acute kidney injury (AKI) is a serious complication of hematopoietic stem
cell transplantation (HSCT).(2) Methods: The aim was to identify the incidence, severity, and …

Evaluation of venous thromboembolism prophylaxis protocol in hematopoietic cell transplant patients

A Lee, C Badgley, M Lo, MT Banez, L Graff… - Bone Marrow …, 2023 - nature.com
Hematopoietic cell transplant (HCT) recipients are at risk for thromboembolic and bleeding
complications. There is limited evidence regarding the optimal approach to managing …

A multicentre, multinational, prospective, observational registry study of defibrotide in patients diagnosed with veno-occlusive disease/sinusoidal obstruction syndrome …

M Mohty, ML Battista, D Blaise, E Calore… - Bone Marrow …, 2021 - nature.com
Severe hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a
potentially life-threatening complication of haematopoietic cell transplantation (HCT). This …

[HTML][HTML] Prospective assessment of risk biomarkers of sinusoidal obstruction syndrome after hematopoietic cell transplantation

Y Han, A Bidgoli, BP DePriest, A Méndez… - JCI insight, 2023 - ncbi.nlm.nih.gov
BACKGROUND Currently, no laboratory tests exist to stratify for the risk of developing
sinusoidal obstruction syndrome (SOS), an early endothelial complication after …

[HTML][HTML] Low-dose total body irradiation added to fludarabine and busulfan reduced-intensity conditioning reduces graft failure in patients with myelofibrosis

CW Freyer, DV Babushok, NV Frey, SI Gill… - … and Cellular Therapy, 2022 - Elsevier
Allogeneic hematopoietic cell transplantation (alloHCT) is indicated for patients with
intermediate-risk or high-risk myelofibrosis (MF) and remains the sole potential cure …

[HTML][HTML] Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapy

L Iovino, LA Thur, S Gnjatic, A Chapuis… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
COVID-19, the syndrome caused by the infection with SARS-CoV-2 coronavirus, is
characterized, in its severe form, by interstitial diffuse pneumonitis and acute respiratory …