[HTML][HTML] Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

From intestinal colonization to systemic infections: Candida albicans translocation and dissemination

JL Sprague, L Kasper, B Hube - Gut Microbes, 2022 - Taylor & Francis
Candida species are the most prevalent cause of invasive fungal infections, of which
Candida albicans is the most common. Translocation across the epithelial barrier into the …

The hyphal-specific toxin candidalysin promotes fungal gut commensalism

SH Liang, S Sircaik, J Dainis, P Kakade, S Penumutchu… - Nature, 2024 - nature.com
The fungus Candida albicans frequently colonizes the human gastrointestinal tract, from
which it can disseminate to cause systemic disease. This polymorphic species can transition …

Friendly fungi: symbiosis with commensal Candida albicans

TY Shao, DB Haslam, RJ Bennett, SS Way - Trends in immunology, 2022 - cell.com
Mucosal tissues are constitutively colonized by a wide assortment of host-adapted microbes.
This includes the polymorphic fungus Candida albicans which is a primary target of human …

[HTML][HTML] Healthy Diet and Lifestyle improve the gut microbiota and help combat fungal infection

S Jawhara - Microorganisms, 2023 - mdpi.com
Western diets are rapidly spreading due to globalization, causing an increase in obesity and
diseases of civilization. These Western diets are associated with changes in the gut …

[HTML][HTML] The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans

ID Jacobsen - Current Clinical Microbiology Reports, 2023 - Springer
Abstract Purpose of Review The fungus Candida albicans has evolved to live in close
association with warm-blooded hosts and is found frequently on mucosal surfaces of healthy …

[HTML][HTML] IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis

N Millet, NV Solis, D Aguilar, MS Lionakis… - Nature …, 2022 - nature.com
During infection the host relies on pattern-recognition receptors to sense invading fungal
pathogens to launch immune defense mechanisms. While fungal recognition and immune …

[HTML][HTML] Intestinal fungi and antifungal secretory immunoglobulin A in Crohn's disease

M Sun, J Ju, H Xu, Y Wang - Frontiers in Immunology, 2023 - frontiersin.org
The human gastrointestinal tract harbors trillions of commensal microorganisms. Emerging
evidence points to a possible link between intestinal fungal dysbiosis and antifungal …

[HTML][HTML] Antibodies as Models and Tools to Decipher Candida albicans Pathogenic Development: Review about a Unique Monoclonal Antibody Reacting with …

J Leroy, K Lecointe, P Coulon, B Sendid, R Robert… - Journal of Fungi, 2023 - mdpi.com
Candidiasis, caused mainly by Candida albicans, a natural commensal of the human
digestive tract and vagina, is the most common opportunistic fungal infection at the mucosal …

[HTML][HTML] Microbial underdogs: exploring the significance of low-abundance commensals in host-microbe interactions

G Han, S Vaishnava - Experimental & Molecular Medicine, 2023 - nature.com
Our understanding of host-microbe interactions has broadened through numerous studies
over the past decades. However, most investigations primarily focus on the dominant …