Therapeutic potential of pyrrole and pyrrolidine analogs: an update
N Jeelan Basha, SM Basavarajaiah, K Shyamsunder - Molecular Diversity, 2022 - Springer
The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has
been a versatile field of study for a long time for its diverse biological and medicinal …
been a versatile field of study for a long time for its diverse biological and medicinal …
Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases
Z Wang, W Bian, Y Yan, DM Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and
link cellular metabolism with membrane excitability. The action potential converts electricity …
link cellular metabolism with membrane excitability. The action potential converts electricity …
Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai …
Y Liu, C Xu, Y Wang, C Yang, G Pu… - Clinical and …, 2023 - Taylor & Francis
Objective Hypertension is one of the leading causes of human death and disability. MTHFR
and MTRR regulate folate metabolism and are closely linked to hypertension, although the …
and MTRR regulate folate metabolism and are closely linked to hypertension, although the …
Maturity-onset diabetes of the young: Mutations, physiological consequences, and treatment options
Maturity-Onset Diabetes of the Young (MODY) is a rare form of diabetes which affects
between 1% and 5% of diagnosed diabetes cases. Clinical characterizations of MODY …
between 1% and 5% of diagnosed diabetes cases. Clinical characterizations of MODY …
[HTML][HTML] A synonymous KCNJ11 variant leading to MODY13: A case report and literature review
C Chen, Y Piao, Y Sang - Molecular Genetics and Metabolism Reports, 2024 - Elsevier
Background Maturity-onset diabetes of the young, type 13 (MODY13) is a specific subclass
of monogenic diabetes mellitus that does not exhibit the typical clinical manifestations of …
of monogenic diabetes mellitus that does not exhibit the typical clinical manifestations of …
A novel mutation KCNJ11 R136C caused KCNJ11-MODY
Y Chen, X Hu, J Cui, M Zhao, H Yao - Diabetology & Metabolic Syndrome, 2021 - Springer
A young female patient, diagnosed with diabetes mellitus at the age of 28 years old in 2009,
carries KCNJ11 R136C by whole exome sequencing and her daughter doesn't carry this …
carries KCNJ11 R136C by whole exome sequencing and her daughter doesn't carry this …
Clinical and functional characterization of a novel KCNJ11 (c. 101G> A, p. R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13
X Lv, J Gao, J Yang, Y Zou, J Chen, Y Sun, J Song… - Endocrine, 2024 - Springer
Purpose This study aimed to describe the clinical features, diagnostic and therapeutic
course of a patient with MODY13 caused by KCNJ11 (c. 101G> A, p. R34H) and how it …
course of a patient with MODY13 caused by KCNJ11 (c. 101G> A, p. R34H) and how it …
A facile halogen assisted intramolecular cyclization of (E)‐3‐(substituted benzylidene)‐1‐(substituted phenyl) pyrrolidine‐2, 5‐dione
GB Deshmukh, NS Patil, AB Kanagare… - Journal of …, 2024 - Wiley Online Library
A straightforward method for producing pyrrolo‐chromenes involved the utilization of a Wittig
reaction, where maleimides reacted with ortho‐hydroxy benzaldehyde. This reaction yields …
reaction, where maleimides reacted with ortho‐hydroxy benzaldehyde. This reaction yields …
Clinical and genetic characteristics of maturity‐onset diabetes of the young type 13: A systematic review of the literature
Y Chen, X Hu, M Zhao - Journal of Diabetes, 2024 - Wiley Online Library
Objective Maturity‐onset diabetes of the young type 13 (MODY13), a rare type of monogenic
diabetes, is often misdiagnosed as type 1 or type 2 diabetes. To improve early diagnosis …
diabetes, is often misdiagnosed as type 1 or type 2 diabetes. To improve early diagnosis …
Case report: Neonatal diabetes mellitus caused by KCNJ11 mutation presenting with intracranial hemorrhage
B Wu, W Xu - Frontiers in Neurology, 2023 - frontiersin.org
Neonatal diabetes mellitus (NDM) is a rare type of monogenic diabetes. At present, most
published studies have focused on the types of gene mutations associated with NDM and …
published studies have focused on the types of gene mutations associated with NDM and …