ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Interindividual differences of drug response are an important cause of treatment failures and
adverse drug reactions. The identification of polymorphisms explaining distinct phenotypes …

Abstract P-glycoprotein (ABCB1, MDR1) belongs to the ABC transporter family transporting
a wide range of drugs and xenobiotics from intra-to extracellular at many biological …

Inter-individual variability in drug response and the emergence of adverse drug reactions
are main causes of treatment failure in cancer therapy. Recently, membrane transporters …

P‐glycoprotein (PGP) is a polymorphic transporter encoded by the ABCB1 gene that
contributes to the access of xenobiotics into the brain. There is no report on associations …

In vivo and in vitro studies have demonstrated that P-glycoprotein (P-gp) plays a very
significant role in the ADME processes (absorption, distribution, metabolism, excretion) and …

Drug resistance is a severe limitation of chemotherapy of various malignancies. In particular
efflux transporters of the ATP-binding cassette family such as ABCB1 (P-glycoprotein), the …

Aim The aim of this study was to obtain pharmacogenetic data in a Vietnamese population
on genes coding for proteins involved in the elimination of drugs currently used for the …

We investigated whether the 2677G> T/A and 3435C> T polymorphisms of adenosine
triphosphate‐binding cassette subfamily B member 1 (ABCB1) affect the efficacy of …

The genetic variability, haplotype profile and ethnic differences of MDR1 polymorphisms in
healthy Roma and Hungarian populations were analyzed and the results were compared …