IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of
physiological functions traditionally associated with host defense, immune cell regulation …

Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney
disease (CKD), respectively. Despite the common association, the role of uric acid in the …

The fructose survival hypothesis proposes that obesity and metabolic disorders may have
developed from over-stimulation of an evolutionary-based biologic response (survival …

Background and aims Colchicine reduces the risk of cardiovascular events in patients with
coronary disease. Colchicine has broad anti-inflammatory effects and part of the …

Background The residual cardiovascular risk in subjects receiving guideline-recommended
therapy is related to persistent vascular inflammation and IL-6 represents a target for its …

NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent
of myocardial damage after myocardial infarction (MI). The purpose of this study was to …

Background: Evidence from recent studies has shown the benefits of colchicine for patients
with coronary artery disease. The aim was to assess the effect of colchicine treatment on …

Background: Worldwide, cardiovascular disease (CVD) is the leading cause of premature
death. The proinflammatory cytokine interleukin 6 (IL-6) is a essential marker of innate …

Cardiovascular diseases (CVDs) are a leading cause of global morbidity and mortality,
significantly driven by chronic inflammation. Interleukin-6 (IL-6) and interleukin-1β (IL-1β) …

Nonresolving inflammation contributes to the progression of atherosclerosis, a chronic
disease characterized by the accumulation of lipid-rich arterial plaques infiltrated with …