Updated clinical pharmacokinetics and pharmacodynamics of oxycodone
M Kinnunen, P Piirainen, H Kokki, P Lammi… - Clinical …, 2019 - Springer
Global oxycodone consumption has increased sharply during the last two decades, and, in
2008, oxycodone consumption surpassed that of morphine. As oxycodone was synthesized …
2008, oxycodone consumption surpassed that of morphine. As oxycodone was synthesized …
Chemistry and synthesis of major opium alkaloids: a comprehensive review
B Kaboudin, M Sohrabi - Journal of the Iranian Chemical Society, 2021 - Springer
Among analgesic drugs, the opioid class of compounds still remains one of the most
important medicines for severe and chronic pain treatment. Hence, developing novel and …
important medicines for severe and chronic pain treatment. Hence, developing novel and …
PharmGKB summary: oxycodone pathway, pharmacokinetics
R Huddart, M Clarke, RB Altman… - Pharmacogenetics and …, 2018 - journals.lww.com
Background Oxycodone is a semisynthetic opioid derived from thebaine and is an opioid-
receptor agonist used to provide analgesia to patients 1. It has been in clinical use since …
receptor agonist used to provide analgesia to patients 1. It has been in clinical use since …
The analgesic efficacy and pharmacokinetics of epidural oxycodone after gynaecological laparotomy: a randomized, double‐blind, double‐dummy comparison with …
P Piirainen, H Kokki, H Hautajärvi… - British journal of …, 2018 - Wiley Online Library
Aim The aim of the present study was to compare the analgesic efficacy of epidural and
intravenous (iv) oxycodone at the same dose. Methods In this randomized, double‐blind …
intravenous (iv) oxycodone at the same dose. Methods In this randomized, double‐blind …
Population pharmacokinetics of oxycodone in plasma and cerebrospinal fluid after epidural and intravenous administration
M Lamminsalo, P Piirainen, H Kokki… - Expert Opinion on …, 2019 - Taylor & Francis
Objectives: To establish the first plasma and cerebrospinal fluid (CSF) oxycodone
population pharmacokinetic (PopPK) model after epidural (EPI) and intravenous (IV) …
population pharmacokinetic (PopPK) model after epidural (EPI) and intravenous (IV) …
Oxycodone concentrations in the central nervous system and cerebrospinal fluid after epidural administration to the pregnant ewe
M Kinnunen, H Kokki, H Hautajärvi… - Basic & Clinical …, 2019 - Wiley Online Library
The main sites of the analgesic action of oxycodone are the brain and spinal cord. The
present study describes the concentrations of oxycodone and its metabolites in the brain …
present study describes the concentrations of oxycodone and its metabolites in the brain …
Pharmacokinetics and Bioequivalence Evaluation of a New Oxycodone Tamper-Resistant Tablet Administered with an Opioid Antagonist in Patients with Chronic Pain
Z Luo, J Miao, S Shu, Y Wang, X Zhu, C Hu… - Clinical Drug …, 2020 - Springer
Abstract Background and Objectives Oxycodone tamper resistant (OTR) is a new extended-
release abuse-deterrent formulation providing improvements in the tamper resistant …
release abuse-deterrent formulation providing improvements in the tamper resistant …
[PDF][PDF] Ranta, VP, Valitalo, P..., & Kokki, M.(2019)
M Lamminsalo, P Piirainen - … of ox codone in … - scholarlypublications …
Objectives: To establish the first plasma and cerebrospinal fluid (CSF) oxycodone
population pharmacokinetic (PopPK) model after epidural (EPI) and intravenous (IV) …
population pharmacokinetic (PopPK) model after epidural (EPI) and intravenous (IV) …
[PDF][PDF] Oxycodone in labour analgesia: pharmacokinetics, central nervous system concentrations and foetal exposure
M Kinnunen - 2020 - erepo.uef.fi
Oxycodone is a semi-synthetic opioid derived from thebaine. Global consumption of
oxycodone has surpassed that of morphine, which was for long considered as the 'gold …
oxycodone has surpassed that of morphine, which was for long considered as the 'gold …