[HTML][HTML] Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products

B He, X Bai, Y Tan, W Xie, Y Feng, GY Yang - Synthetic and Systems …, 2022 - Elsevier
UDP-Glycosyltransferases (UGTs) catalyze the transfer of nucleotide-activated sugars to
specific acceptors, among which the GT1 family enzymes are well-known for their function in …

Flavonoids, terpenoids, and polyketide antibiotics: Role of glycosylation and biocatalytic tactics in engineering glycosylation

UM Vasudevan, EY Lee - Biotechnology advances, 2020 - Elsevier
Flavonoids, terpenoids, and polyketides are structurally diverse secondary metabolites used
widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as …

Utilization of glycosyltransferases as a seamless tool for synthesis and modification of the oligosaccharides-A review

MY Ali, F Liaqat, MI Khazi, S Sethupathy… - International Journal of …, 2023 - Elsevier
Glycosyltransferases (GTs) catalyze the transfer of active monosaccharide donors to
carbohydrates to create a wide range of oligosaccharide structures. GTs display strong …

Promiscuity and specificity of eukaryotic glycosyltransferases

A Biswas, M Thattai - Biochemical Society Transactions, 2020 - portlandpress.com
Glycosyltransferases are a large family of enzymes responsible for covalently linking sugar
monosaccharides to a variety of organic substrates. These enzymes drive the synthesis of …

Glycorandomization: A promising diversification strategy for the drug development

B Goel, N Tripathi, D Mukherjee, SK Jain - European Journal of Medicinal …, 2021 - Elsevier
Glycorandomization is a natural product derivatization strategy in which different sugar
moieties are linked to the aglycone part of the naturally existing glycosides to create …

Cascade biocatalysis systems for bioactive naringenin glucosides and quercetin rhamnoside production from sucrose

SB Thapa, RP Pandey, P Bashyal, T Yamaguchi… - Applied microbiology …, 2019 - Springer
Two sustainable and cost-effective cascade enzymatic systems were developed to
regenerate uridine diphosphate (UDP)-α-d-glucose and UDP-β-l-rhamnose from sucrose …

[HTML][HTML] De novo sequencing of Bletilla striata (Orchidaceae) transcriptome and identification of genes involved in polysaccharide biosynthesis

J Niu, G Zhao, Z Mi, L Chen, S Liu, S Wang… - … and molecular biology, 2020 - SciELO Brasil
Bletilla striata polysaccharide (BSP) is the main component of Bletilla striata, which has
important pharmacological and pharmacological effects; however, due to the lack of genetic …

Exploring 3-O-glycosylations of 20 (R)-dammarane ginsenosides and the catalytic mechanism underlying the stereoselectivity with the combined assistance of …

LL Hong, YN Liu, JQ Kong - International Journal of Biological …, 2024 - Elsevier
Glycosylation at C3-OH is the favorable modification for pharmaceutical activities and
diversity expansion of 20 (R)-dammarane ginsenosides. The 3-O-glycosylation, exclusively …

Glycodiversifying Testosterone with a Promiscuous Glycosyltransferase OsSGT2 from Ornithogalum saundersiae

YN Liu, LL Hong, M Liu, QC Guo… - ACS Synthetic Biology, 2021 - ACS Publications
The diversity expansion of testosterone17-O-β-glycosides (TGs) will increase the probability
of screening more active molecules from their acetylated derivatives with anticancer …

[HTML][HTML] N-Glucosylation in Corynebacterium glutamicum with YdhE from Bacillus lichenformis

OJ Amoah, HT Nguyen, JK Sohng - Molecules, 2022 - mdpi.com
Corynebacterium glutamicum is traditionally known as a food-grade microorganism due to
its high ability to produce amino acids and its endotoxin-free recombinant protein expression …